DATE	INDUSTRY SPONSORED RESEARCH	FUNDING SOURCE	STUDY OUTCOME

DATE	INDUSTRY SPONSORED RESEARCH	FUNDING SOURCE	ADVERSE REACTION IDENTIFIED	SAFETY OF ASPARTAME SUPPORTED
1976	Koch R, Schaeffler G, Shaw NF. Results of Loading Doses of Aspartame by two Phenylketonuric (PKU) Children Compared with two Normal Children. J Toxicol Environ Health 1976;2(2):459-469.	Searle		X
1976	Stern SB, Bleicher SJ, Flores A, et al. Administration of Aspartame in Non-Insulin Dependent Diabetics, J Toxicol Environ Health 1976;2:429-439.	Searle		X
1976	Knopp RH, Brandt K, Arky RA. Effects of Aspartame in Young Persons During Weight Reduction. J Toxicol Environ Health 1976;2:417-428.	Searle		X
1976	Frey GH. Use of Aspartame By Apparently Healthy Children and Adolescents. J Toxicol Environ Health 1976;2:401-415.	Searle		X
1976	Koch R, Shaw KN, Williamson M, Haber M. Use of Aspartame in Phenylketonuric Heterozygous Adults. J Toxicol Environ Health 1976;2(2):453-7.	Searle		X
1977	Stegink LD, Filer LJ Jr, Baker GL. Effect of Aspartame and Aspartate Loading Upon Plasma and Erythrocyte Free Amino Acid Levels in Normal Adult Volunteers. J Nutr 1977;107:1837-1845.	Searle		X
1979	Stegink LD, Filer LJ Jr, Baker GL. Plasma, Erythrocyte and Human Milk Levels of Free Amino Acids in Lactating Women Administered Aspartame or Lactose. J Nutr 1979;109:2173-2181.	Searle		X
1980	Potts WJ, Bloss JL, Nutting EF. Biological Properties of Aspartame-Evaluation of Central Nervous System Effects. J Environ Pathol Toxicol 1980;3(5-6):341-353.	Searle		X
1980	Saunders FJ, Pautsch WF, Nutting EF. The Biological Properties of Aspartame. IV. Examination for Endocrine Like Activities. J Exper Pathol Toxicol 1980;3:363-373.	Searle		X
1980	Lennon HD, Metcalf LE, Mares SE. The Biological Properties of Aspartame. IV. Effects on Reproduction and Lactation. J Environ Pathol Toxicol 1980;3:375-386.	Searle		X
1980	Bianchi RG, Muir ET, Cook DL, Nutting EF et al. The Biological Properties of Aspartame. III. Actions Involving the Gastrointestinal System, J. Environ Pathol Toxicol 1980;3:355-362.	Searle		X
1980	Aspinall RL, Saunders RN, Pautsch WF, Nutting SF. The Biological Properties of Aspartame: Effects on a Variety of Physiological Parameters Related to Inflammation and Metabolism. J Environ Pathol Toxicol 1980 Jun-Jul;3(5-6):387-95.	Searle		X
1981	Stegink LD, Brummel MC, McMartin K, et al. Blood Methanol Concentrations in Normal Adult Subjects Administered Abuse Doses of Aspartame. J Toxicol Environ Health 1981;7:281-290.	Searle		X
1981	Stegink LD, Filer LJ Jr, Baker GL. Plasma and Erythrocyte Concentrations of Free Amino Acids in Adult Humans Administered Abuse Doses of Aspartame. J Toxicol Environ Health 1981;7:291-305	Searle		X
1981	Stegink LD, Filer LJ Jr, Baker GL. Effect of Aspartame and Sucrose Loading in Glutamate-Susceptible Subjects. Am J Clin Nutr 1981;34(9):1899-1905.	Searle		X
1981	Ishii H. Incidence of Brain Tumors in Rats Fed Aspartame. Toxicology Letters 1981;7:433-437.	Ajinomoto & Searle		X
1981	Ishii H, Koshimizu T, Usami S, Fujimoto T. Toxicity of Aspartame and its Diketopiperazine for Wistar Rats by Dietary Administration for 104 weeks. Toxicology 1981;21:91-94.	Ajinomoto & Searle		X
1982	Stegink LD, Filer LJ Jr, Baker GL. Effect of Aspartame Plus Monosodium L-Glutamate Ingestion on Plasma and Erythrocyte Amino Acid Levels in Normal Adult Subjects Fed a High Protein Meal. Am J Clin Nutr 1982;36:1145-1152.	Searle		X
1983	Stegink LD, Filer LJ Jr, Baker GL. Plasma Amino Acid Concentrations in Normal Adults Fed Meals with Added Monosodium L-Glutamate and Aspartame. J Nutr 1983;113:1851-1860.	Searle		X
1983	Filer LJ Jr, Baker GL, Stegink LD. Effect of Aspartame Loading on Plasma and Erythrocyte Free Amino Acid Concentrations in One Year Old Infants. J Nutr 1983;113:1591-1599.	General Foods Corp.		X
1983	Stegink LD, Brummel MC, Filer LJ Jr, Baker GL. Blood Methanol Concentrations in One-Year Old Infants Administered Graded Doses of Aspartame. J Nutr 1983;113:1600-1606.	General Foods Corp.		X
1984	Roak-Foltz and Leveille. Projected Aspartame Intake: Daily Ingestion of Aspartic Acid, Phenylalanine, and Methanol. In: Stegink L, Filer L (eds). Aspartame: Physiology and Biochemistry, New York: Marcel Dekker Inc., 1984.	Searle		X
1985	Sturtevant F. Does Aspartame Cause Methanol Toxicity. In: Wurtman and Ritter-Walker (eds). Dietary Phenylalanine and Brain Function. Boston: Birkhauser, 1988, pp. 163-168.	Searle		X
1985	Nehrling JK, Kobe P, McLane MP, et al. Aspartame Use by Persons with Diabetes. Diabetes Care 1985;8:415-17.	Searle		X
1985	Gaull GE. Aspartame and Seizures. Lancet 1985;2(8469-70):1431	Nutra sweet		X
1986	Torii K, Mimura T, Takasaki Y, Ichimura M. Dietary Aspartame with Protein on Plasma and Brain Amino Acids, Brain Monoamines and Behavior in Rats. Physiol Behav 1986;36(4):765-72.	Ajinomoto		X
1986	Torii K, Mimura T, Takasaki Y, Ichimura M. Effect of Mealing on Plasma and Brain Amino Acid, and Brain Monoamine in Rats after Oral Aspartame. Physiol Behav 1986;36(4):759-64.	Ajinomoto		X
1986	Szucs EF, Barrett KE, Metcalfe DD. The Effect of Aspartame on Mast Cells and Basophils. Food Chem Toxic 1986;24(2):171-174	Intl. Life Sciences		X
1987	Schiffman SS, Buckley CE 3rd Sampson HA. Aspartame and Susceptibility to Headache. N Engl J Med 1987;317(19):1181-1185.	Nutra sweet		X
1987	Ryan-Harshman M, Leiter LA, Anderson GH. Phenylalanine and Aspartame Fail to Alter Feeding Behavior, Mood and Arousal in Men. Physiology and Behavior 1987;39:247-253.	Intl. Life Sciences		X
1987	Stegink LD, Filer LJ Jr, Baker GL. Plasma Amino Acid Concentrations in Normal Adults Ingesting Aspartame and Monosodium L-Glutamate as Part of a Soup/Beverage Meal. Metabolism 1987;36(11):1073-1079.	Nutra sweet		X
1987	Cho ES, Coon JD, Stegink LD. Plasma and Urine Diketopiperazine Concentrations in Normal Adults Ingesting Large Quantities of Aspartame. Food Chem Toxicol 1987;25(7):499-504.	Searle		X
1988	Kanders BS, Lavin PT, Kowalchuck M, et al. An Evaluation of the Effect of Aspartame on Weight Loss. Appetite 1988;Volume II(Suppl 1):73-84.	Nutra sweet		X
1988	Shaywitz, et. al. Effects of Aspartame on Seizures in Children. In: Wurtman, Ritter-Walker (eds.) Dietary Phenylalanine and Brain Function. Boston:Birkhauser, 1988, pp. 163-168.	Nutra sweet		X
1988	Leiter, et. al., Effects of Phenylalanine and Aspartame on Mealtime Food Intake and Behavior in Adult Males. In: Wurtman, Ritter-Walker (eds.) Dietary Phenylalanine and Brain Function. Boston:Birkhauser, 1988, pp. 296-299.	Intl. Life Sciences		X
1988	Keybach and Allen, Resources for Inferential Estimates of Aspartame Intake in the United States. In: Wurtman, Ritter-Walker (eds.) Dietary Phenylalanine and Brain Function. Boston:Birkhauser, 1988, pp. 365-372.	Nutra sweet		X
1988	Jobe and Dailey. Role of Monoamines in Seizure Predisposition in the Genetically Epilepsy-Prone Rat. In: Wurtmann and Ritter-Walker (eds.). Dietary Phenylalanine and Brain Function. Boston:Birkhauser, 1988, pp. 127-130.	Nutra sweet		X
1988	Horwitz DL, McLane M, Cobe P. Response to Single Dose of Aspartame or Saccharin by NIDDM Patients. Diabetes Care 1988;2:230-34.	Nutra sweet		X
1989	McAnulty PA, Collier MJ, Enticott J, et al. Absence of Development Effects in CFI Mice Exposed to Aspartame in Utero. Fundam Appl Toxicol 1989 Aug;13(2):296-302.	Nutra sweet		X
1989	Reilly MA, Debler EA, Fleischer A. Lack of Effect of Chronic Aspartame Ingestion on Aminergic Receptors in Rat Brain. Biochem Pharmacol 1989;38(23):433904361.	Nutra sweet		X
1989	Stegink LD, Filer LJ Jr, Bell EF, Ziegler EE, Tephly TR. Effect of Repeated Ingestion of Aspartame-Sweetened Beverage on Plasma Amino Acid, Blood Methanol and Blood Formate Concentration in Normal Adults. Metabolism 1989;38(4):357-363.	Nutra sweet		X
1989	Stegink LD, Filer LJ Jr, Bell EF, et al. Repeated Ingestion of Aspartame-Sweetened Beverage: Effect on Plasma Amino Acid Concentrations in Individuals Heterozygous for Phenylketonuria. Metabolism 1989;38(1):78-84.	Searle		X
1989	Gupta V, Cochran C, Parker TF, et al. Effect of Aspartame on Plasma Amino Acid Profiles of Diabetic Patients with Chronic Renal Failure. Am J Clin Nutr 1989;49:1302-6.	Nutra sweet		X
1989	Leon AS, Hunninghake DB, Bell C, et al. Safety of Long-term Large Doses of Aspartame. Arch Intern Med 1989;149(10):2318-24.	Searle		X
1989	Dailey JW, Lasley SM, Mishra PK, et al. Aspartame Fails to Facilitate Pentylenetetrazol-Induced Convulsions in CD-1 Mice. Toxicol Appl Pharmacol 1989;98:475-486.	Nutra sweet		X
1989	Anderson GH, Saravis S, Schacher R. Zlotein S, Leiter LA et al. Aspartame: Effect on Lunch Time Food Intake Appetite and Hedonic Response in Children. Appetite 1989;13:93-103.	Intl. Life Sciences		X
1989	Holder MD. Effects of Perinatal Exposure to Aspartame on Rat Pups. Neurotoxicology and Teratology 1989;11(1):1-6.	Nutra sweet		X
1989	Cain DP, Boon F, Bevan M. Failure of Aspartame to Affect Seizure Susceptibility in Kindled Rats. Neuropharmacology 1989;28(4):433-435.	Nutra sweet		X
1989	Carlson HE, Shaw JH. Aspartame and its Constituent Amino Acids: Effect on Prolactin, Cortisol, Growth Hormone, Insulin and Glucose in Normal Humans. Am J Clin Nutr 1989;49(3):427-432	Nutra sweet		X
1990	Saravis S, Schachar R, Zlotkin S, Leiter LA, Anderson GH. Aspartame: Effects on Learning Behavior and Mood. Pediatrics 1990;86(1):75-83.	Intl. Life Sciences		X
1990	Stegink LD, Filer LJ Jr, Bell EF, et al. Repeated Ingestion of Aspartame-Sweetened Beverages: Further Observations in Individuals Heterozygous for Phenylketonuria. Metabolism 1990;39(10):1076-1081.	Searle		X
1990	Lapierre KA, Greenblatt DJ, Goddard JE, Harmatz JS, Shader RI. The Neuropsychiatric Effects of Aspartame in Normal Volunteers. J Clin Pharmacol 1990:30(5):454-460.	Nutra sweet		X
1990	Burns TS, Starget WW, Hurwitz A. Bioavailability of Phenylalanine and Aspartame from Aspartame (20 mg/kg) in Capsules and Solution. Metabolism 1990;39(11):1200-3	Nutra sweet		X
1991	Koeppe RA, Shulkion BL, Rosenspire KC. Effect of Aspartame-Derived Phenylalanine on Neutral Amino Acid Uptake in Human Brain: A Positron Emission Tomography Study. J Neurochem 1991;1526-1535.	Nutra sweet		X
1991	Garriga MM, Berkebile C, Metcalfe DD. A Combined Single - Blind, Double Blind, Placebo-Controlled Study to Determine the Reproducibility of Hypersensitivity Reactions to Aspartame. J Allergy Clin Immunol 1991 April;87(4):821-7.	Intl. Life Sciences		X
1991	Mullenix PJ, Tassinari MS, Schunior A, Kernan WJ. No Change in Spontaneous Behavior of Rats After Oral Doses of Aspartame, Phenylalanine and Tyrosine. Fundam Appl Toxicol 1991; 16(3):495-505.	Nutra sweet		X
1991	Moser RH. Aspartame. South Med J 1991;84(12):1509-10.	Nutra sweet		X
1991	Daily JW, Lasley SM, Burger RL, et al. Amino Acids, Monoamines and Audiogenic Seizures in Genetically Epilepsy-Prone Rats: Effects of Aspartame. Epilepsy Res 1991;8:122-133.	Nutra sweet		X
1991	Fernstrom JD, Fernstrom MH, Massoudi MS. In Vivo Tyrosine Hydroxylation in Rat Retina: Effect of Aspartame Ingestion in Rats Pretreated with P-Chlorophenylalanine. Am J Clin Nutr 1991;53(4):923-9.	Nutra sweet		X
1991	Burns TS, Stargel WW, Tschanz C, Kotsonis PN, Hurwitz A, et al. Aspartame and Sucrose Produce a Similar Increase in the Plasma Phenylalanine to Large Neutral Amino Acid Ratio in Healthy Subjects. Pharmacology 1991;43:210-219.	Nutra sweet		X
1991	Butchko HH, Kotsonis FN. Acceptable Daily Intake vs. Actual Intake: The Aspartame Example. J Am Coll Nutr 1991;10(3):258-266.	Nutra sweet		X
1992	Hjelle JJ, Dudley RE, Marietta MP, et al. Plasma Concentrations and Pharmacokinetics of Phenylalanine in Rats and Mice Administered Aspartame. Pharmacology 1992;44(1):48-60.	Nutra sweet		X
1993	Karstaedt PJ, Pincus JH. Aspartame Use in Parkinson's Disease. Neurology 1993;43(3 pt 1):611-613.	Intl. Life Sciences		X
1993	Geha R, Buckley CE, Greenberger P, et al. Aspartame is no More Likely than Placebo to Cause Urticaria/Angioedema: Results of a Multicenter, Randomized, Double-Blind, Placebo-Controlled, Crossover Study. J Allergy Clin Immunol 1993;92:513-20.	Nutra sweet		X
1993	Hertelendy ZI, Mendenhall CL, Rouster SD, Marshall L, Weesner R. Biochemical and Clinical Effects of Aspartame in Patients with Chronic, Stable Alcoholic and Liver Disease. Am J Gastroenterol 1993;88(5):737-743.	Nutra sweet		X
1994	Trefz F, deSonneville L, Matthis P, et al. Neuropsychological and Biochemical Investigations in Heterozygotes for Phenylketonuria During Ingestion of High Dose Aspartame. Human Genetics 1994;93:369-374.	Nutra sweet		X
1994	Shaywitz BA., Anderson GM, Novotny EJ, et al. Aspartame has no Effect on Seizures or Epileptiform Discharges in E pileptic Children. Ann Neurol 1994;35:98-103.	Nutra sweet		X
1994	Shaywitz BA, Sullivan CM, Anderson GM, et al. Aspartame, Behavior, and Cognitive Function in Children With Attention Deficit Disorder. Pediatrics 1994;93:70-75.	Nutra sweet		X
1994	Wolraich Ml, Lindgren SD, Stumbo PJ, et al. Effects of Diets High in Sucrose or Aspartame on the Behavior and Cognitive Performance of Children. N Engl J Med 1994;330(5):301-307.	Intl. Life Sciences		X
1994	Drewnowski A, Massein C, Louis-Syulvestre J, et al. Comparing the Effects of Aspartame and Sucrose on Motivational Ratings, Taste Preferences, and Energy Intakes in Humans. Am J Clin Nutr 1994;59:338-65.	Nutra sweet		X
1994	Moser RH. Aspartame and Memory Loss. JAMA 1994;272(19):1543.	Nutra sweet		X
1994	Butchko HH, et al. Postmarketing Surveillance of Food Additives. In: Nutritional Toxicology. Kotsonig, Machky and Jhelle, (eds.) New York: Raven Press Ltd. 1994.	Nutra sweet		X
1994	Drewnowski A, Massier C, Louis-Sylvestre J, et al. The Effects of Aspartame Versus Sucrose on Motivational Ratings, Taste Preferences, and Energy Intakes in Obese and Lean Women. International Journal of Obesity 1994;18:570-578.	Nutra sweet		X
1995	Rowan AJ, Shaywitz BA, Tuchman L, et al. Aspartame and Seizure Susceptibility: Results of a Clinical Study in Reportedly Sensitive Individuals. Epilepsia 1995:36(3):270-5.	Nutra sweet		X