www.DORway.comDavid Oliver Rietz's DORway to Discovery
Who Is Dr. Olney?
CURRICULUM VITAE
John W. Olney, M.D.
BORN: October 23, 1931 – Marathon, Iowa
MARITAL STATUS: Married
CITIZENSHIP: U.S.A.
EDUCATION:Iowa University, Iowa City, Iowa – B.A. 1956
Iowa University, Iowa City, Iowa – M.D. 1963
HONORS:
Borden Undergraduate Research Award in Medicine 1963
NIMH Research Career Development Award 1968-1978
NIMH Research Scientist Award 1978-1998
Wakeman Award for Research in the Neurosciences 1992
Dana Foundation Award for Pioneering Achievement in Health 1994
Peter H. Raven Lifetime Award, Service & Accomplishments in Science 1996
The Society Biological Psychiatry, Lifetime Achievements Award 1996
Member, Institute of Medicine, National Academy of Sciences 1996
SOCIETY MEMBERSHIPS:
Society for Biological Psychiatry
New York Academy of Sciences
Society for Neuroscience
Psychiatric Research Society
American Medical Association
American Psychiatric Association
American Psychopathological Association
Association for Research in Nervous and Mental Diseases
American Association of Neuropathologists
International Brain Research Organization
CERTIFICATION: Neurology and Psychiatry, 1970
MILITARY SERVICE: U.S. Army 1954-1956
INTERNSHIPS & RESIDENCIES:
Internship (rotation) Kaiser Permanente Foundation
San Francisco, California 1963-1964
Resident in Psychiatry, Washington University
School of Medicine, St. Louis, Missouri 1964-1968
RESEARCH EXPERIENCE, ACADEMIC APPOINTMENTS, HOSPITAL APPOINTMENTS
Biological Science Trainee, Washington University
School of Medicine, St. Louis 1966-1968
Career Investigator Awardee, Washington University
School of Medicine 1968-
Assistant Psychiatrist, Renard Hospital, St. Louis 1968-
Consulting Psychiatrist, Malcolm Bliss Mental
Health Center, St. Louis 1968-
Instructor in Psychiatry
Washington University School of Medicine 1968-1969
Assistant Professor of Psychiatry
Washington University School of Medicine 1969-1972
Associate Professor of Psychiatry
Washington University School of Medicine 1972-1977
Associate Professor of Neuropathology
Washington University School of Medicine 1976-1977
Professor of Psychiatry
Washington University School of Medicine 1977-
Professor of Neuropathology
Washington University School of Medicine 1977-
Member, NIMH Research Career Scientist
Award Committee 1984-1988
Chairman, NIMH Research Career Scientist
Award Committee 1986-1988
BIBLIOGRAPHY
1. Olney JW. An electron microscopic study of synapse formation,
receptor outer segment development and other aspects of developing mouse
retina. Invest Ophthal 7, 250-268, 1968.
2. Olney JW. Centripetal sequence of appearance of receptor-bipolar
synaptic structures in developing mouse retina. Nature 218, 281-282, 1968.
3. Olney JW. Brain lesions, obesity and other disturbances in mice
treated with monosodium glutamate. Science 164, 719-721, 1969.
4. Olney JW. Glutamate-induced retinal degeneration in neonatal mice.
Electron microscopy of the acutely evolving lesion. J Neuropathol Exp
Neurol 28, 455-474, 1969.
5. Olney JW and Sharpe LG. Brain lesions in an infant rhesus monkey
treated with monosodium glutamate. Science 166, 386-388, 1969.
6. Olney JW and Ho OL. Brain damage in infant mice following oral intake
of glutamate, aspartate or cysteine. Nature, 227, 609-610, 1970.
7. Perez VJ, Olney JW, Cicero TJ, Moore BW and Bahn BA. Wallerian
degeneration in rabbit optic nerve: cellular localization in the central
nervous system of S-100-14-3-2 proteins. J Neurochem 17, 511-519, 1970.
8. Olney JW. Glutamate-induced neuronal necrosis in the infant mouse
hypothalamus: an electron microscopic study. J Neuropathol Exp Neurol 30,
75-90, 1971.
9. Olney JW, Ho OL and Rhee V. Cytotoxic effects of acidic and sulphur-
containing amino acids on the infant mouse central nervous system. Exp
Brain Res 14, 61-76, 1971.
10. Olney JW, Sharpe LG and Feigin RD. Glutamate-induced brain damage in
infant primates. J Neuropathol Exp Neurol 3l, 464-488, 1972.
11. Perez VJ and Olney JW. Accumulation of glutamic acid in the arcuate
nucleus of the hypothalamus of the infant mouse following subcutaneous
administration of monosodium glutamate. J Neurochem 19, 1777-1781, 1972.
12. Olney JW, Ho OL, Rhee V and Schainker B. Cysteine-induced brain
damage in infant and fetal rodents. Brain Res 45, 309-313, 1972.
13. Olney JW. A model for manipulating CNS cytotoxic effects between
neuronal and non-neuronal compartments. J Neuropathol Exp Neurol 3l, l80,
1972.
14. Olney JW. Neurotoxic effects of acidic and sulphur-containing amino
acids on developing central nervous system. J Neuropathol Exp Neurol 3l,
182, 1972.
15. Perez VJ, Olney JW and Robin SJ. Glutamate accumulation in infant
mouse hypothalamus: influence of temperature. Brain Res 59, 181-189, 1973.
16. Olney JW, Ho OL and Rhee V. Brain damaging potential of protein
hydrolysates. N Engl J Med 289, 391-395, 1973.
17. Olney JW. Status of monosodium glutamate revisited. Am J Clin Nutr
26, 683-689, 1973.
18. Olney JW, Ho OL, Rhee V and deGubareff T. Neurotoxic effects of
glutamate. N Engl J Med 289, 1374-1375, 1973.
19. Cunningham L, Rich CL, Woodruff RA and Olney JW. Creatinine
phosphokinase and psychiatric illness. Brit J Psychiat 124, 887-89l, 1974.
20. Olney JW. Occult mechanisms of brain dysfunction. In: Drugs and the
Developing Brain. A Vernadakis and N Weiner (Eds), Plenum, New York, 1974.
21. Olney JW. Toxic effects of glutamate and related amino acids on the
developing central nervous system. In: Heritable Disorders of Amino Acid
Metabolism. WN Nyhan (Ed), John Wiley, New York, 1974, pp. 501-512.
22. Schainker B and Olney JW. Glutamate-type hypothalamic-pituitary
syndrome in mice treated with aspartate or cysteate in infancy. J Neural
Transm 35, 207-215, 1974.
23. Olney JW, Rhee V and Ho OL. Kainic acid: a powerful neurotoxic
analogue of glutamate. Brain Res 77, 507-512, 1974.
24. Cicero TJ, Meyer ER, Wiest WB, Olney JW and Bell RD. Effects of
chronic morphine administration on the reproductive system of the male rat.
J Pharmacol Exp Ther 192, 542-548, 1975.
25. Sharpe LG, Olney JW, Ohlendorf C, Lyss A, Zimmerman M and Gale B.
Brain damage and associated behavioral deficits following the administration
of L-cysteine to infant rats. Pharmacol Biochem Behav 3, 291-298, 1975.
26. Olney JW, Misra CH and deGubareff T. Cysteine-S-sulfate: brain
damaging metabolite in sulfite oxidase deficiency. J Neuropathol Exp Neurol
34, 167-176, 1975.
27. Misra CH and Olney JW. Cysteine oxidase in brain. Brain Res 97,
117-126, 1975.
28. Olney JW, Sharpe LG and deGubareff T. Excitotoxic amino acids.
Neurosci Abst 1, 371, 1975.
29. Olney JW. Another view of Aspartame. In: Sweeteners; Issues and
Uncertainties. Natl Acad Science Forum, US Govt Printing Office, 1975.
30. Olney JW. Brain damage and oral intake of certain amino acids. In:
Transport phenomena in the Nervous System: Physiological and Pathological
Aspects. G Levi, L Battistin and A Lajtha (Eds), Plenum, New York, 1976.
31. Olney JW, Schainker B and Rhee V. Chemical lesioning of the
hypothalamus as a means of studying neuroendocrine function. In: Hormones,
Behavior and Psychopathology. EJ Sachar (Ed), Raven, New York, 1976.
32. Olney JW, Cicero TJ, Meyer ER and deGubareff T. Acute glutamate-induced
elevations in serum testosterone and luteinizing hormone. Neurosci Abst 2,
677, 1976.
33. Anandaraj MPJA, Jayaram HN, Olney JW and Cooney DA. Alanosine–a new
anti-tumor antibiotic with properties of an analog and antagonist of L-
aspartic and L-glutamic acids. Presented at Meeting of American Cancer
Society, 1976.
34. Price MT, Olney JW and Cicero TJ. Proliferation of lamellar whorls in
arcuate neurons of the hypothalamus of castrated and morphine-treated male
rats. Cell Tissue Res 171, 277-284, 1976.
35. Olney JW, Cicero TJ, Meyer ER and deGubareff T. Acute glutamate-induced
elevations in serum testosterone and luteinizing hormone. Brain Res 112,
420-424, 1976.
36. Misra CH and Olney JW. Synthesis of cysteine-35S-sulfate. J Labelled
Compounds Radiopharma�ceuticals 13, 137-140, 1976.
37. Olney JW, Misra CH and Rhee V. Brain and retinal damage from the
lathyrus excitotoxin, b-N-oxalyl-L-ab-diaminopropionic acid (ODAP). Nature
264, 659-661, 1976. .
38. Perez VJ, Olney JW, Frolichstein CF, Martin JF and Cannon WO. Regional
uptake of neurotoxic and nontoxic amino acids in vivo by the infant mouse
brain. Biochem Pharmacol 25, 1415-1419, 1976.
39. Olney JW, Rhee W, and deGubareff T. Neurotoxic effects of glutamate on
mouse area postrema. Brain Res 120, 151-157, 1977.
40. Olney JW and deGubareff T. Excitotoxic amino acids and Huntington’s
chorea. J Neuropathol Exp Neurol 36, 619, 1977.
41. Olney JW, Fuller T and deGubareff T. Alanosine–an antileukemic agent
with glutamate-like neurotoxic properties. J Neuropathol Exp Neurol 36,
619, 1977.
42. Misra CH, Mena EE, Rhee V and Olney JW. Intracellular distribution of
cysteine oxidase in the rat central nervous system. Abst Fed Proc 36, 2522,
1977.
43. Price MT, Olney JW and Cicero TJ. Proliferation of lamellar whorls in
arcuate neurons of the hypothalamus of male rats treated with estradiol
benzoate or cyproterone acetate. Cell Tissue Res 182, 537-540, 1977.
44. deGubareff T and Olney JW. Intraventricular administration of potent
excitotoxins may yield clues to location of glutareceptive neurons.
Neurosci Abst 3, 515, 1977.
45. Olney JW, deGubareff T and Misra CH. D and L-isomers of homocysteic
acid compared for neurotoxicity. Neurosci Abst 3, 518, 1977.
46. Price MT, Olney JW and Cicero TJ. Acute elevation of serum luteinizing
hormone induced by low systemic doses of powerful neuroexcitatory analogs of
glutamate. Neurosci Abst 3, 355, 1977.
47. Olney JW and deGubareff T. The fate of synaptic receptors in the
kainate lesioned striatum. Brain Res 140, 340-343, 1978.
48. Olney JW and deGubareff T. Glutamate neurotoxicity and Huntington’s
chorea. Nature 271, 557-559, 1978.
49. Olney JW and Rhee V. Neurotoxic effects of glutamate on primate area
postrema. J Neuropathol Exp Neurol 37, 669, 1978.
50. Olney JW. Neurotoxicity of excitatory amino acids. In: Kainic Acid as
a Tool in Neurobiology. E McGeer, JW Olney, P McGeer (Eds), Raven, New
York, 1978, pp 95-121.
51. Olney JW and deGubareff T. Extreme sensitivity of olfactory cortical
neurons to kainic acid toxicity. In: Kainic Acid as a Tool in
Neurobiology. E McGeer, JW Olney and P McGeer (Eds), Raven, New York, 1978
pp 201-217.
52. Olney JW and Price MT. Excitotoxic amino acids as neuroendocrine
probes. In: Kainic Acid as a Tool in Neurobiology. E McGeer, JW Olney and
P McGeer (Eds), Raven Press, New York, 1978, pp 239-263.
53. Price MT, Olney JW and Cicero TJ. Acute elevations of serum luteinizing
hormone induced by kainic acid, N-methylaspartic acid or homocysteic acid.
Neuroendocrinology 26, 352-358, 1978.
4. McGeer E, Olney JW and McGeer P (Eds). In: Kainic Acid as a Tool in
Neurobiology. Raven Press, New York, 1978.
55. Price MT, Olney JW and Cicero JT. Release of luteinizing hormone
induced by N-methylaspartate is blocked by GABA or taurine but not by
dopamine antagonists. Neurosci Abst 4, 352, 1978.
56. Fuller T and Olney JW. Naloxone and the effects of systemically
administered kainic acid. Neurosci Abst 4, 423, 1978.
57. Olney JW, deGubareff T and Fuller TA. Extreme sensitivity of olfactory
cortical neurons to kainic acid toxicity. Neurosci Abst 4, 583, 1978.
58. Price MT, Olney JW, Mitchell MV, Fuller T and Cicero TJ. Luteinizing
hormone releasing action of N-methyl aspartate is blocked by GABA or taurine
but not by dopamine antagonists. Brain Res 158, 461-465, 1978.
59. Perez VJ, Olney JW, Martin JF and Cannon WO. Minimal tissue
concentrations of glutamate required to produce necrosis of hypothalamic
neurons. Biol Neonate 35, 17-22, 1979.
60. Olney JW. Excitotoxic amino acids: research applications and safety
implications. In: Glutamic Acid: Advances in Biochemistry and Physiology.
S Garratini, LJ Filer, MR Kare, WA Reynolds and R Wurtman (Eds), Raven, New
York, 1979.
61. Olney JW, deGubareff T and Labruyere J. a-Aminoadipate blocks the
neurotoxic action of N-methylaspartate. Life Sci 25, 537-540, 1979.
62. Olney JW, Fuller T and deGubareff T. Acute dendrotoxic changes in the
hippocampus of kainate treated rats. Brain Res 176, 91-100, 1979.
63. Olney JW. Excitotoxic amino acids and Huntington’s disease. In:
Advances of Neurology, Huntington’s Disease, Vol. 23. TN Chase, A Wexler, A
Barbeau (Eds), Raven, New York, 1979, pp 609-624.
64. Fuller TA and Olney JW. Effects of morphine or naloxone on kainic acid
neurotoxicity. Life Sci 24, 1793-1798, 1979.
65. Fuller TA and Olney JW. Morphine enhances and diazepam suppresses the
neurotoxicity of systemically administered kainic acid. Neurosci Abst 5,
556, 1979.
66. Price MT, Olney JW, Anglim M, Mitchell V and Buchsbaum S. The LH-
releasing action of N-methylaspartate is reversible and is dependent on
arcuate hypothalamic neurons. Neurosci Abst 5, 456, 1979.
67. Olney JW, Price MT, Fuller TA, deGubareff T, Anglim M, Labruyere J and
Mitchell V. Blockade by a-amino�adipate of the neurotoxic and LH-releasing
actions of N-methylaspartate. Neurosci Abst 5, 595, 1979.
68. Price MT, Olney JW, Anglim M, Buchsbaum S and Mitchell V.
Cholinomimetics inhibit N-methylaspartate-induced LH release. Endocr Soc
Abst 61st Mtg, p 304, 1979.
69. Price MT, Olney JW, Anglim M and Buchsbaum S. Reversible action of N-
methylaspartate on gonadotrophin neuroregulation. Brain Res 176, 165-168,
1979.
70. Olney JW and Price MT. GABA inhibition of N-methylaspartate stimulated
luteinizing hormone release. Brain Res Bull 4, 703, 1979.
71. Olney JW. Excitotoxic mechanisms of neurotoxicity. Ch 19. In:
Experimental and Clinical Neurotoxicology. P Spencer and H Schaumburg
(Eds), Williams & Wilkins, Baltimore, 1980, pp 272-294.
72. Olney JW and Price MT. Neuroendocrine interactions of excitatory and
inhibitory amino acids. Brain Res Bull 5, Suppl 2, 361-368, 1980.
73. Schwob JE, Fuller T, Price JL and Olney JW. Widespread patterns of
neuronal damage following systemic or intracerebral injections of kainic
acid: a histological study. Neuroscience 5, 991-1014, 1980.
74. Olney JW. Excitatory neurotoxins as food additives: an evaluation of
risk. Neurotoxicology 2, 163-192, 1980.
75. Olney JW, Labruyere J and deGubareff T. Brain damage in mice from
voluntary ingestion of glutamate and aspartate. Neurobehav Toxicol 2, 125-
129, 1980.
76. Fuller TA and Olney JW. Kainate neurotoxicity is suppressed by some
anticonvulsants but not others. Neurosci Abst 6, 400, 1980.
77. deGubareff T, Olney JW and Collins JF. Stereospecificity of the
gliotoxic and anti-neurotoxic actions of alpha aminoadipate. Neurosci Abst
6, 148, 1980.
78. Price MT, Olney JW, Lowry OH and Buchsbaum S. Serum osmolarity and
glutamate-induced brain damage. Neurosci Abst 6, 830, 1980.
79. Olney JW, Fuller TA, Collins R and deGubareff T. Dipiperidinoethane
mimics kainate convulsions and brain damage. Neurosci Abst 6, 799, 1980.
80. Collins RC, McLean M, Lochman EW, Klunk W and Olney JW. Kainic acid
causes limbic seizures. Epilepsia 21, 186, 1980.
81. Collins RC, McLean M and Olney JW. Cerebral metabolic response to
systemic kainic acid: 14-C-deoxyglucose studies. Life Sci 27, 855-862,
1980.
82. Olney JW, deGubareff T and Collins JF. Stereospecificity of the
gliotoxic and anti-neurotoxic actions of alpha aminoadipate. Neurosci Lett
19, 277-282, 1980.
83. Olney JW, Fuller TA, Collins RC and deGubareff T. Systemic
dipiperidinoethane mimics the convulsant and neurotoxic actions of kainic
acid. Brain Res 200, 231-235, 1980.
84. Olney JW. Kainic acid and other excitotoxins: a comparative analysis.
In: Glutamate as a Neurotransmitter. G DiChiara and GL Gessa (Eds), Raven,
New York 1981, pp 375-384.
85. Olney JW and Price MT. Neuroendocrine effects of excitotoxic amino
acids. In: Glutamate as a Neurotransmitter. G DiChiara and GL Gessa
(Eds), Raven, New York, 1981, pp 423-432.
86. Price MT, Olney JW, Lowry OH and Buchsbaum S. Uptake of exogenous
glutamate and aspartate by circumventricular organs but not other regions of
brain. J Neurochem 36, 1774-1780, 1981.
87. Price MT, Olney JW and Haft R. Age-related changes in glutamate
concentration and synaptosomal glutamate uptake in adult rat striatum. Life
Sci 28, 1365-1370, 1981.
88. Olney JW and Sloviter RS. Ultrastructural analysis of hippocampal
damage produced by sustained perforant path stimulation in the rat. J
Neuropath Exp Neurol 40, 340, 1981.
89. Olney JW. In: Neurosciences Research Program Bulletin, Excitatory Amino
Acid Neurotoxins: Selectivity, Specificity, and Mechanisms of Action, Vol
19, No 4, 1981.
90. Olney JW, Fuller TA and deGubareff T. Kainate-like neurotoxicity of
folates. Nature 292, 165-167, 1981.
91. Olney JW, Labruyere J, Collins JF and Curry K. D-Aminophosphonovalerate
is 100-fold more powerful than D-alpha-aminoadipate in blocking N-
methylaspartate neurotoxicity. Brain Res 221, 207-210, 1981.
92. Olney JW, Fuller TA, deGubareff T and Labruyere J. Intrastriatal folic
acid mimics the distant but not local brain damaging properties of kainic
acid. Neurosci Lett 25, 207-210, 1981.
93. Zucker DK, Wooten GF, Lothman EW and Olney JW. Neuropathological
changes associated with intravenous kainic acid. J Neuropathol Exp Neurol
40, 324, 1981.
94. Fuller TA, Olney JW and Conboy VT. Diazepam markedly attenuates the
neurotoxicity of folic acid. Neurosci Abst 7, 811, 1981.
95. Price MT, Haft R and Olney JW. Chronic fluphenazine treatment induces
changes in glutamate concentrations and glutamate high affinity uptake in
adult rat striatum. Neurosci Abst 7, 714, 1981.
96. Olney JW, Fuller TA, deGubareff T and Labruyere J. Folates mimic
distinctive features of kainate (but not glutamate) neurotoxicity.
Neurosci Abst 7, 810, 1981.
97. deGubareff T, Olney JW and Sloviter RS. Ultrastructural comparison of
hippocampal damage produced by electrical stimulation of the perforant path
and that induced by kainic acid, folic acid or dipiperidinoethane. Neurosci
Abst 7, 590, 1981.
98. Fuller TA and Olney JW. Only certain anticonvulsants protect against
kainate neurotoxicity. Neurobehav Toxicol Teratol 3, 355-361, 1981.
99. Collins RC and Olney JW. Focal cortical seizures cause distant
thalamic lesions. Science 218, 177-179, 1982.
100. Olney JW. The toxic effects of glutamate and related compounds in
the retina and the brain. Retina 2, 341-359, 1982.
101. Fuller TA, Olney JW and Conboy VT. Naloxone blocks morphine
enhancement of kainic acid neurotoxicity. Life Sci 3l, 229-233, 1982.
102. Olney JW, Collins JF and deGubareff T. Dipiperidinoethane
neurotoxicity clarified. Brain Res 249, 195-197, 1982.
103. Young E, Olney J and Akil H. Delta, but not mu, receptors increase
selectively in the thalamus of monosodium glutamate lesioned rats.
Presented at International Narcotics Research Club, 1982.
104. Fuller TA, Buchsbaum S and Olney JW. Morphine enhancement of kainate
neurotoxicity is opiate receptor specific. Neurosci Abst 8, 1014, 1982.
105. Honchar MP, Olney JW and Sherman WR. Systemic pilocarpine or
physostigmine induces seizures and brain damage in lithium-treated rats.
Neurosci Abst 8, 773, 1982.
106. Labruyere J, Olney JW and Collins RC. Focal neocortical seizures cause
distant lesions within seizure pathways. Neurosci Abst 8, 1012, 1982.
107. Olney JW, deGubareff T and Labruyere J. Cholinergic agents mimic
seizure-related aspects of kainate neurotoxicity. Neurosci Abst 8, 773,
1982.
108. Price MT, Pusateri ME, Lowry OH and Olney JW. Entry of exogenous
aspartate into circumventricular organs but not other regions of brain.
Neurosci Abst 8, 848, 1982.
109. Scallet AC and Olney JW. Combined monosodium glutamate and bipiperidyl
mustard lesions prevent naloxone blockade of stress-induced hyperthermia and
produce obesity in rats. Neurosci Abst 8, 369, 1982.
110. Tal J, Price MT and Olney JW. Failure of neuroactive amino acids to
influence luteinizing hormone release from isolated rat or monkey pituitary.
Neurosci Abst 8, 62, 1982.
111. Collins RC, Lothman EW and Olney JW. Status Epilepticus in the limbic
system–biochemical and pathological changes. In: Advances in Neurology
Vol. 34 – Status Epilepticus. Delgado-Escueta AV, Wasterlain CG, Treiman DM
and Porter RJ (Eds), Raven, New York, 1983, pp 277-288.
112. Olney JW, deGubareff T and Labruyere J. Seizure-related brain damage
induced by cholinergic agents. Nature 301, 520-522, 1983.
113. Collins RC, Olney JW and Lothman ER. Metabolic and pathological
consequences of focal seizures. In: Epilepsy. AA Ward, Jr (Ed), Raven, New
York,1983, pp 87-107.
114. Young E, Olney J and Akil H. Selective alterations of opiate receptor
subtypes in monosodium glutamate-treated rats. J Neurochem 40, 1558-1564,
1983.
115. Olney JW. Excitotoxins: an overview. In: Excitotoxins. Fuxe K,
Roberts P and Schwarcz R (Eds), Macmillan, London, 1983, pp 82-96.
116. Honchar MP, Olney JW and Sherman WR. Systemic cholinergic agents
induce seizures and brain damage in lithium-treated rats. Science 220, 323-
325, 1983.
117. Tal J, Price MT, Olney JW, Oettinger M and Sharf M. In vitro studies
on LH release from rat and monkey anterior pituitaries by neuroactive amino
acids. Israel J Med Sci 19, 579, 1983.
118. Olney JW, deGubareff T and Sloviter RS. “Epileptic” brain damage in
rats induced by sustained electrical stimulation of the perforant path. II.
Ultrastructural analysis of acute hippocampal pathology. Brain Res Bull 10,
699-712, 1983.
119. Tal J, Price MT and Olney JW. Neuroactive amino acids influence
gonadotrophin output by a suprapituitary mechanism in either rodents or
primates. Brain Res 273, 179-182, 1983.
120. Olney JW and Price MT. Excitotoxic amino acids as neuroendocrine
research tools. In: Methods in Enzymology, Vol 103. Conn PM (Ed), Academic
Press, New York, 1983, pp 379-393.
121. Olney JW, Honchar MP and Sherman WR. Diazepam prevents lithium-
pilocarpine neurotoxicity in rats. Neurosci Abst 9, 401, 1983.
122. Scallet AC and Olney JW. Effects of glutamate and/or bipiperidyl
mustard treatment on hypothalamic proopiomelanocortin neurons, food intake,
obesity index and blood insulin. Neurosci Abst 9, 281, 1983.
123. Stewart G, Price MT and Olney JW. N-Methylaspartate, a useful
excitotoxin for lesioning substantia innominata neurons in the rat.
Neurosci Abst 9, 355, 1983.
124. Faris PL, Scallet AC, Olney JW, Della-Fera MA and Baile CA. Behavioral
and immunohistochemical analysis of the function of cholecystokinin in the
hypothalamic paraventricular nucleus. Neurosci Abst 9, 184, 1983.
125. Price MT, Pusateri ME, Crow SE, Buchsbaum S, Olney JW and Lowry OH.
Uptake of exogenous aspartate into circumventricular organs but not other
regions of adult mouse brain. J Neurochem 42, 740-744, 1984.
126. Olney JW, Collins RC and Sloviter RS. Excitotoxic mechanisms of
epileptic brain damage. In: Advances in Neurology. Delgado-Escueta AV, Ward
AA, Woodbury DM and Porter RJ (Eds), Raven, New York, pp 857-877, 1986.
127. Faris PL, McLaughlin CL, Baile CA and Olney JW. Autoimmunization
against cholecystokinin (CCK) potentiates morphine analgesia. Fed Proc 43,
935, 1984.
128. Olney JW, Price MT, Samson L and Labruyere J. The ionic basis of
excitotoxin-induced neuronal necrosis. Neurosci Abst 10, 24, 1984.
129. Labruyere J, Olney JW and Price MT. Brain damage resulting from
intraamygdaloid administration of D-tubocurarine. Neurosci Abst 10, 891,
1984.
130. Samson L, Olney JW, Price MT and Labruyere J. Kynurenate protects
against excito toxin-induced neuronal necrosis in chick retina. Neurosci
Abst 10, 24, 1984.
131. Price MT, Labruyere J and Olney JW. Does calcium mediate excitotoxin-
induced neuronal necrosis? Neurosci Abst 10, 24, 1984.
132. Faris PL, McLaughlin CL, Baile CA and Olney JW. Modulation of morphine
analgesia by peripheral cholecystokinin (CCK) and b-endorphin (End).
Neurosci Abst 10, 675, 1984.
133. Stewart GR, Hartman BK, Cozzari C and Olney JW.
Cholineacetyltransferase immunohistochemical evaluation of an excitotoxin
lesion of nucleus basalis. Neurosci Abst 10, 443, 1984.
134. Clifford DB, Olney JW, Zorumski CF. Lithium-pilocarpine seizures: in
vitro hippocampal slice studies. Neurosci Abst 10, 552, 1984.
135. Zorumski CF, Collins RC, Olney JW and Clifford DB. Lithium-pilocarpine
seizures: in vivo studies. Neurosci Abst 10, 552, 1984.
136. Honchar MP, Price MT, Olney JW and Sherman WR. Effects of lithium and
cholinergic agents depend on cholinergic projections to hippocampus and
cingulate cortex. Neurosci Abst 10, 1186, 1984.
137. Olney JW. Excitatory transmitters and epilepsy-related brain damage.
In: International Review of Neurobiology, Vol 27, Bradley RJ (Ed), 337-362,
1985.
138. Olney JW. Excitotoxic food additives–relevance of animal studies to
human safety. Neurobehav Toxicol Teratol 6, 455-462, 1984.
139. Price MT, Olney JW, Samson L and Labruyere J. Calcium influx
accompanies but does not cause excitotoxin-induced neuronal necrosis. Brain
Res Bull 14, 369-376, 1985.
140. Faris PL, McLaughlin CL, Baile CA, Olney JW and Komisaruk BR. Morphine
analgesia potentiated but tolerance not affected by active immunization
against cholecystokinin. Science 226, 1215-1217, 1984.
141. Scallet AC and Olney JW. Components of hypothalamic obesity:
bipiperidyl-mustard lesions add hyperphagia to monosodium glutamate-induced
hyperinsulinemia. Brain Res 374, 380-384, 1986.
142. Olney JW. Aspartate. In: Encyclopedia of Neuroscience. G. Adelman
(Ed) Birkhauser, Boston, 1987, p. 80.
143. Olney JW. Glutamate. In: Encyclopedia of Neuroscience. G. Adelman
(Ed) Birkhauser, Boston, 1987, pp. 468-470.
144. Olney JW. Food Additives, Excitotoxic. In: Encyclopedia of
Neuroscience. G. Adelman (Ed) Birkhauser, Boston, 1987, pp. 436-438.
145. Faris PL, Della-Fera MA, Baile CA and Olney JW. Comparison of the
distribution of cholecystokinin and opioid peptides in rat hypothalamus.
Fed Proc 44, 1725, 1985.
146. Scallet AC and Olney JW. Developmental damage to rat brain
circumventricular organs (CVOs) enhances morphine analgesia in adults.
Behav Teratol Soc Mtg, 1985.
147. Della-Fera MA, Miceli MD, Baile CA, Faris P and Olney J. Deficiency of
CCK-containing neurons in PVN of hamster brain corresponds with failure of
CCK-8 to reduce feeding after injections into the hypothalamic
paraventricular nucleus (PVN) of hamsters. Washington Spring Symposium, DC,
May 2-5, 1985.
148. Faris PL and Olney JW. Suppression of food intake in rats by
microinjection of cholecystokinin (CCK) to the paraventricular nucleus
(PVN). Neurosci Abst 11, 39, 1985.
149. Scallet AC, Faris PL, Beinfeld MC and Olney JW. Neurotoxic
hypothalamic lesions alter the content of cholecystokinin in anterodorsal
hypothalamus and pituitary. Neurosci Abst 11, 54, 1985.
150. Olney JW. Excitotoxic amino acids. News Physiol Sci (NIPS) 1, 19-23,
1986.
151. Rothman SM and Olney JW. Glutamate and the pathophysiology of hypoxic-
ischemic brain damage. Ann Neurol 19, 105-111, 1986.
152. Stewart GR, Price M, Olney JW, Hartman BK and Cozzari C. N-
Methylaspartate: an effective tool for lesioning basal forebrain cholinergic
neurons of the rat. Brain Res 369, 377-382, 1986.
153. Olney JW, Price MT, Samson L and Labruyere J. The role of specific
ions in glutamate neurotoxicity. Neurosci Lett 65, 65-71, 1986.
154. Faris PL, Beinfeld MC, Scallet AC, Johannessen JN and Olney JW.
Increase in hypothalamic cholecystokinin following acute and chronic
morphine. Brain Res 367, 405-407, 1986.
155. Olney JW. Inciting excitotoxic cytocide among central neurons. In:
Excitatory Amino Acids and Epilepsy. R Schwarcz and Y Ben-Ari (Eds),
Plenum, NY, 1986, pp 631-645.
156. Olney JW, Price MT, Fuller TA, Labruyere J, Samson L, Carpenter M and
Mahan K. The anti-excitotoxic effects of certain anesthetics, analgesics
and sedative-hypnotics. Neurosci Lett 68, 29-34, 1986.
157. Khachaturian H, Akil H, Brownstein MJ, Olney JW, Voigt KH and Watson
SJ. Further characterization of the extra-arcuate alpha-melanocyte
stimulating hormone-like material in hypothalamus: biochemical and
anatomical studies. Neuropeptides 7, 291 313, 1986.
158. Olney JW, Price MT, Shahid Salles K, Labruyere J, Ryerson R, Mahan K.
L-homocysteic acid: a potent endogenous excitotoxin and putative
transmitter. Neurosci Abst 12, 380, 1986.
159. Labruyere J, Fuller TA, Olney JW, Price MT, Zorumski C and Clifford D.
Phencyclidine and ketamine protect against kainic acid-induced seizures and
seizure-related brain damage. Neurosci Abst 12, 344, 1986.
160. Price MT, Olney JW, Fuller TA, Labruyere J, Samson L, Carpenter M and
Mahan K. The anti-excitotoxic effects of certain anesthetics, analgesics,
and sedative-hypnotics. Neurosci Abst 12, 342, 1986.
161. Shahid Salles K, Price MT, Ryerson R, Ray J and Olney JW. Dissociative
anesthetics and sigma opiates powerfully block NMA neurotoxicity but do not
bind at the NMA receptor. Neurosci Abst 12, 60, 1986.
162. Stewart GR, Carnes KM, Olney JW, Price JL and Fuller TA. A basal
forebrain cholinergic projection to the nucleus of the lateral olfactory
tract. Neurosci Abst 12, 355, 1986.
163. Prewitt D, Stewart GR, Kalmbach S, Olney JW, Hartman BK, Cozzari C.
Neuronal ectopias and the basal forebrain cholinergic system of the rodent.
Neurosci Abst 12, 443, 1986.
164. Steinmen JL, Faris PL and Olney JW. Further evidence for vagal
involvement in the periheral peptidergic modulation of nociception.
Neurosci Abst 12, 1490, 1986.
165. Faris PL, Kettinger JP and Olney JW. Vagotomy attenuates the increase
in feeding following microinjections of cholecystokinin-antiserum to the
hypothalamic paraventricular nucleus. Neurosci Abst 12, 595, 1986.
166. Clifford DB, Olney JW, Collins RC, Maniotis A, Zorumski CF. Lithium-
pilocarpine and pilocarpine induced seizures: metabolism and neuropathology.
Neurosci Abst 12, 696, 1986.
167. Olney JW. Excitotoxins and selective neuronal death. In: CIBA
Foundation Symposium 126, John Wiley and Sons Limited, Chichester, 1987.
168. Olney JW. Excitatory amino acids and neuropsychiatric disorders. In:
Excitatory Amino Acid Transmission. T.P. Hicks, D. Lodge and H. McLennon
(Eds), Alan R. Liss, Inc., N.Y., pp 217-224, 1986.
169. Olney JW. Excitatory transmitters and neuropsychiatric disorders. In:
Neuronal Control of Bodily Function: Neurobiology of Amino Acids, Peptides
and Trophic Factors. Ferrendelli JA, Collins RC, Johnson EM (Eds), Kluwer
Acad Pubs, Dordrecht, Netherlands, 51-61, 1988.
170. Olney JW, Price MT, Shahid Salles K, Labruyere J, Ryerson R, Mahan K,
Frierdich G, and Samson L. L-homocysteic acid: An endogenous excitotoxic
ligand of the NMDA receptor. Brain Res Bull 19, 597-602 1987.
171. Clifford DB, Olney JW, Maniotis A, Collins RC and Zorumski CF. The
functional anatomy and pathology of lithium-pilocarpine and high-dose
pilocarpine seizures. Neurosci 23, 953-968, 1987.
172. Rothman SM and Olney JW. Excitotoxicity and the NMDA receptor.
TINS 10, 299-302, 1987.
173. Olney J, Price M, Shahid Salles K, Labruyere J, Frierdich G. MK-801
powerfully protects against N-methyl aspartate neurotoxicity. Eur J
Pharmacol 141, 357-361 1987.
174. Olney JW. Endogenous Excitotoxins and Neuropathological Disorders.
In: Excitatory Amino Acids in Health and Disease. D. Lodge (Ed), John Wiley
& Sons Ltd., England, 1988, pp 337-351.
175. Olney JW, Price MT, Labruyere J, Silverman E, Mueller M.
Comparative efficacy of various agents in preventing glutamate-induced or
ischemic neuronal degeneration in chick retina. Neurosci Abst 13, 1030,
1987.
176. Price MT, Olney JW, Shahid Salles K., Labruyere J and Frierdich G.
MK-801 powerfully protects against N-methyl aspartate neurotoxicity.
Neurosci Abst 13, 1556, 1987.
177. Fuller TA, Lawrence JJ and Olney JW. Blockade of N-methylaspartate-
induced arcuate nucleus damage by PCP, MK-801 and related compounds.
Neurosci Abst 13, 1475, 1987.
178. Clifford DB, Benz A, Olney JW and Zorumski CF. MK-801 prevents
thalamic damage induced by focal cortical seizures. Neurosci Abst 13, 1077,
1987.
179. Wozniak DF, Stewart GR, Finger S and Olney JW. Comparison of
behavioral effects of nucleus basalis lesions versus sensorimotor cortex
ablation. Neurosci Abst 13, 1065 1987.
180. Stewart GR, Wozniak DF, Finger S, Olney JW and Cozzari C.
Behavioral consequences of N-methyl aspartate-induced destruction of basal
forebrain cholinergic neurons. Neurosci Abst 13, 1065, 1987.
181. Olney JM, Gray GE, Frierdich G, Shahid Salles K, Labruyere J, Price
MT and Olney JW. Hypoxia-ischemia causes glutamate-like neuropathological
changes in infant rat brain. Neurosci Abst 13, 1553, 1987.
182. Lawrence JJ, Fuller TA and Olney JW. MK-801 and PCP protect against
ischemic neuronal degeneration in the gerbil hippocampus. Neurosci Abst 13,
1079, 1987.
183. Pullan LM, Olney JW, Price MT, Compton RP, Hood WF, Michel J and
Monahan JB. Excitatory amino acid receptor potency and subclass specificity
of sulfur-containing amino acids. J Neurochem 49, 1301-1307, 1987.
184. Scallet AC, Faris PL, Beinfeld MC and Olney JW. Hypothalamic
neurotoxins alter the content of immuno- reactive cholecystokinin in
pituitary. Brain Res 407, 390-393, 1987.
185. Olney JW. Excitotoxic food additives: functional teratological
aspects. In: Progress In Brain Res. Boer, Feenstra, Mirmiran, Swaab, Van
Haaren (Eds), Elsevier, The Netherlands, 1988, pp 283-294.
86. Clifford DB, Olney JW, Benz AM, Fuller TA and Zorumski CF. Ketamine,
phencyclidine and MK-801 protect against kainic acid induced seizure-related
brain damage. Epilepsia 31:382-390, 1990.
187. Stewart GR, Zorumski CF, Price MT and Olney JW. Domoic acid: A
dementia-inducing excitotoxic food poison with kainic acid receptor
specificity. Exp Neurol 110, 127-138, 1990.
188. Olney JW, Price MT, Labruyere J, Shahid Salles K, Frierdich G,
Mueller M and Silverman E. Anti-parkinsonian agents are phencyclidine
agonists and N-methyl aspartate antagonists. Eur J Pharmacol 142, 319-320,
1987.
189. Wozniak DF, Stewart GR, Finger S, Olney JW and Cozzari C. Basal
forebrain lesions impair tactile discrimination and working memory.
Neurobiol Aging 10, 173-179, 1989.
190. Olney JW. Revelations in Excitotoxicology: What next?
Neurochemistry International 12, 12, 1988.
191. Ikonomidou C, Frierdich G, Labruyere J, Price MT and Olney JW.
Hypobaric-ischemic conditions cause glutamate-like damage in infant rat
brain. Neurochemistry International 12, 39, 1988.
192. Olney JW. Revelations in excitotoxicology: What next? In:
Frontiers in Excitatory Amino Acid Research. E.A. Cavalheiro, J. Lehmann,
L. Turski, (Eds), Alan R. Liss, Inc., N.Y., pp 589-596, 1988.
193. Ikonomidou C, Frierdich G, Shahid Salles K, Labruyere J, Price MT and
Olney JW. Glutamate-like damage in infant rat brain produced by hypobaric-
ischemic conditions. In: Frontiers in Excitatory Amino Acid Research.
E.A. Cavalheiro, J. Lehmann, L. Turski, (Eds), Alan R. Liss, Inc., N.Y. pp
657-660, 1988.
194. Olney JW, Ikonomidou C, Mosinger J, Shahid Salles K and Frierdich G.
Role of the N-methyl aspartate receptor in developmental
psychoneuropathology. Neurosci Abst 14, 417, 1988.
195. Price MT, Honore T, Mueller ME, Labruyere J, Silverman E and Olney
JW. CNQX potently and selectively blocks kainate excitotoxicity in the
chick embryo retina. Neurosci Abst 14, 418, 1988.
196. Ikonomidou C, Mosinger J, Shahid Salles K, Labruyere J and Olney JW.
Parallel patterns of hypersensitivity to NMA toxicity and hypobaric/ischemic
damage in developing rat brain. Neurosci Abst 14, 501, 1988.
197. Stewart GR, Mueller ME, Price MT and Olney JW. Neuroplastic
potential of cholinergic neurons that project to the basolateral amygdala.
Neurosci Abst 14, 1222, 1988.
198. Shahid Salles K, Frierdich G, Price MT and Olney JW. Changes in 3H-
QNB and 3H-glutamate binding in rat brain following persistent seizures
induced by lithium/pilocarpine treatment. Neurosci Abst 14, 1329, 1988.
199. Mosinger JL, Price MT, Labruyere J, Mueller ME, Silverman E and
Olney JW. Glutamate blocks kainate neurotoxicity in the chick embryo
retina. Neurosci Abst 14, 417, 1988.
200. Wozniak DF, Olney JW and Kettinger L III. Effects of MK-801 on
memory retention in the rat. Neurosci Abst 14, 941, 1988.
201. Clifford DB, Benz A, Olney JW and Zorumski CF. MK-801 prevents
seizure related brain damage from pilocarpine and lithium-pilocarpine
epidural well induced seizures. Neurosci Abst 14, 863, 1988.
202. Ikonomidou C, Price MT, Mosinger JL, Frierdich G, Labruyere J,
Shahid Salles K and Olney JW. Hypobaric-ischemic conditions produce
glutamate-like cytopathology in infant rat brain. J Neurosci 9, 1693-1700,
1989.
203. Olney JW, Ikonomidou C, Mosinger JL and Frierdich G. MK-801
prevents hypobaric-ischemic neuronal degeneration in infant rat brain. J
Neurosci 9, 1701-1704, 1989.
204. Olney JW. Excitatory amino acids and neuropsychiatric disorders.
Biol Psychiatry 26, 505-525, 1989.
205. Olney JW. Excitotoxicity and NMDA receptors. Drug Dev Res 17, 299-
319, 1989.
206. Ikonomidou C, Mosinger JL and Olney JW. Hypothermia enhances
protective effect of MK-801 against hypoxic/ischemic brain damage in infant
rats. Brain Res 487, 184-187, 1989.
207. Ikonomidou C, Mosinger JL, Shahid Salles K, Labruyere J and Olney JW.
Sensitivity of the developing rat brain to hypobaric/ischemic damage
parallels sensitivity to N-Methyl-Aspartate neurotoxicity. J Neurosci 9,
2809-2818, 1989.
208. Wozniak DF, Stewart GR, Finger S and Olney JW. Comparison of
behavioral effects of nucleus basalis magnocellularis lesions and
somatosensory cortex ablation in the rat. Neuroscience 32, 685-700, 1989.
209. Ikonomidou C, Mosinger JL and Olney JW. Protective effect of low-grade
hypothermia against hypoxic/ischemic brain damage in infant rats. 12th
Biannual Meeting Int Soc Neurochem, Algrave, Portugal, April 23-28, 1989. J
Neurochem Suppl, 1989.
210. Mosinger JL and Olney JW. Photothrombosis-induced ischemic neuronal
degeneration in the rat retina. Invest Ophthalmol & Vis Sci Suppl 30, 136,
1989.
211. Olney JW, Labruyere J and Price, MT. Pathological changes induced in
cerebrocortical neurons by phencyclidine and related drugs. Science 244,
1360-1362. 1989.
212. Olney JW, Labruyere J and Price MT. Neurocytotoxicity of phencyclidine
and MK-801. Biol Psychiatry Abstr 25, 133A, 1989.
213. Steinman JL, Faris PL, Mann PE, Olney JW, Komisaruk BR, Willis WD and
Bodnar RJ. Antagonism of morphine analgesia by nonopioid cold-water swim
analgesia: Direct evidence for collateral inhibition. Neurosci Biobehav Rev
14, 1-7, 1990.
214. Olney JW and Price MT. Excitotoxic amino acids as neuroendocrine
research tools. In: Neuroendo-crine Peptide Methodology. P. Michael Conn
(Ed), Academic Press, Inc., San Diego, Cal., 1989, pp 891-905.
215. Mosinger JL and Olney JW. Photothrombosis-induced ischemic neuronal
degeneration in the rat retina. Exp Neurol 105, 110-113, 1989.
216. Clifford DB, Zorumski CF and Olney JW. Ketamine and MK-801 prevent
degeneration of thalamic neurons induced by focal cortical seizures. Exp
Neurol 105, 272-279, 1989.
217. Olney JW. Glutamate, a neurotoxic transmitter. J Child Neurol 4, 218-
226, 1989.
218. Olney JW and Ikonomidou C. Endogenous excitotoxins and perinatal
hypoxic/ischemic brain damage. Proceedings 6th Capo Boi Conference on
Neuroscience, Cagliari, Italy. June 3, 1989.
219. Olney JW. Excitotoxin-mediated neuron death in youth and old age. In:
Progress in Brain Research, Vol. 86. PD Coleman, GA Higgins and CH Phelps,
(Eds), Elsevier Science Pubs BV, Amsterdam, The Netherlands, 1990, pp 37-51.
220. Olney JW, Labruyere J and Price MT. L-cysteine, an endogenous NMDA-
mimetic excitotoxin that induces generalized ischemia-like neonatal or fetal
brain damage. Neurosci Abst 15, 480, 1989.
221. Price MT, Stewart GR and Olney JW. Procyclidine protects against soman
neurotoxicity, even when administered after onset of convulsions. Neurosci
Abst 15, 1349, 1989.
222. Mosinger JL and Olney JW. Combined treatment with MK-801 and CNQX
prevents ischemic neuronal degeneration in the in vivo rat retina. Neurosci
Abst 15, 45, 1989.
223. Labruyere J, Price MT and Olney JW. NMDA antagonists induce
pathomorphological changes in cerebrocortical neurons. Neurosci Abst 15,
761, 1989.
224. Stewart GR, Wozniak DF, Schmidt RE and Olney JW. Calcification of the
globus pallidus following excitotoxic destruction of the nucleus basalis.
Neurosci Abst 15, 1043, 1989.
225. Olney JW. Excitotoxic Lesions. In: Selective Lesioning in the
Nervous System, Neurosci Short Course Syllabus, 1-12, 1989.
226. Olney JW. Excitotoxicity: An Overview. Proceedings of a symposium on
domoic acid toxicity held at the Health Protection Branch, Health and
Welfare Canada, April 11-12, 1989. In: Canada Diseases Weekly Report
Supplement, Volume 16S1E, September 1990, pp 47-58.
227. Olney JW and Ikonomidou C. Extreme sensitivity to excitotoxic brain
damage in youth and old age. In: Advances in the Biosciences, Vol. 78,
Excitatory Amino Acids and Brain Ischemia Pharmaco-logical and Clinical
Aspects. G Biggio, PF Spano, G Toffano, GL Gessa, (Eds), Pergamon Press,
Oxford, England, 1990, pp 15-28.
228. Olney JW. Excitotoxic amino acids and neuropsychiatric disorders. In:
Annual Review of Pharmacology and Toxicology, Volume 30. R George, AK Cho
and TF Blaschke (Eds), Annu Rev Inc, Palo Alto, CA, 1990, pp 47-71.
229. Wozniak DF, Olney JW, Kettinger L III, Price M and Miller JP.
Behavioral effects of MK-801 in the rat. Psychopharmacology 101, 47-56,
1990.
230. Thurkauf A, de Costa B, Mattson MV, France CP, Price MT, Olney JW,
Woods JH, Jacobson AE and Rice KC. Synthesis, phencyclidine-like
pharmacology, and antiischemic potential of meta-substituted 1-(1-
phenylcyclohexyl)-1,2,3,6-tetrahydropyridines. J Med Chem 33, 2211-2215,
1990.
231. Ikonomidou C, Labruyere J, Benz A and Olney JW. Antagonistic
pharmacology of glutamate neurotoxicity in infant rat brain. Neurosci Abst
15, 767, 1989.
232. Olney JW, Zorumski CF, Stewart GR, Price MT, Wang G and Labruyere J.
Excitotoxicity of L-DOPA and 6-OH-DOPA: Implications for Parkinson’s and
Huntington’s Diseases. Exp Neurol 108, 269-272, 1990.
233. Olney JW, Zorumski C, Price MT and Labruyere J. L-Cysteine, a
bicarbonate-sensitive endogenous excitotoxin. Science 248, 596-599, 1990.
234. Olney JW. Memoirs of an Excitotoxicologist. In: The Neurosciences:
Paths of Discovery, II. F Samson and G Adelman (Eds), Birkh�user Boston
Inc, Cambridge, MA, 1992; pp 169-187.
235. Olney JW. Excitotoxicity: An overview. Biol Psychiatry Abst 27, 90A,
1990.
236. Olney JW, Labruyere J and Price MT. Phencyclidine, dizocilpine and
cerebrocortical neurons: Technical Comments. Science 247, 221, 1990.
237. Olney JW, Price MT, Zorumski CF and Clifford DB. Cholinotoxic
syndromes: Mechanisms and protection. Workshop on convulsions and related
brain damage induced by organophosphorus agents, Aberdeen Proving Ground,
MD, February 1-2, 1990, pp 147-162.
238. Olney JW. Phencyclidine neurotoxicity. In: Neuroscience Year:
Supplement 2, Encyclopedia of Neuroscience, 1992, pp 128-129.
239. Olney JW and Ikonomidou C. Excitotoxic mechanisms operative in youth
and old age. In: Neurobiology of the NMDA receptor: From chemistry to the
clinic. AP Kozikowski and G Barrionuevo (Eds), VCH Publishers, NY, 1991, pp
187-202.
240. Olney JW. Response to Letter to the Editor. Excitatory amino acid
hypothesis of schizophrenia. Biol Psychiatry 28, 553-554, 1990.
241. Olney JW, Labruyere J, Wang GJ, Price MT. Anticholinergics prevent
neurotoxic side effects of NMDA antagonists. Neurosci Abst 16, 1122, 1990
242. Price MT and Olney JW. Excitatory amino acid antagonists as anti-
emetics. Neurosc Abst 16, 377, 1990.
243. Wozniak DF, Stewart GR, Fry B, Kettinger L and Olney JW. Kainate
neurotoxicity in aged rats: A model for studying domoate dementia in aged
humans. Neurosci Abst 16, 197, 1990.
244. Stewart GR, Zorumski CF, Price MT and Olney JW. Domoic Acid: A
dementia-inducing excitotoxic food poison with kainic acid receptor
specificity. Neurosci Abst 16, 1122, 1990.
245. Bai HY, Xiao H, Price MT, Olney JW. Protection against ischemic
neuronal degeneration in vitro or in vivo by honghua, an anti-excitotoxic
chinese herbal medicine. Neurosci Abst 16, 275, 1990.
246. Wang GJ, Labruyere J, Price MT, Olney JW. Extreme sensitivity of
infant animals to glutamate toxicity: Role of NMDA receptors. Neurosci Abst
16, 198, 1990.
247. Olney JW. Excitotoxins and neurological diseases. In: Proceedings of
the XIth International Congress of Neuropathology “Neuropathology”
Supplement 4. XIth ICN Organizing Committee (Eds), The Japanese Society of
Neuropathology, 1991, pp 209-214.
248. Olney JW. Trying to get glutamate out of baby food. Citation Classic,
Current Contents, Life Sciences, 33 (34), 21, 1990; Citation Classic,
Current Contents, Clinical Medicine, 18 (34), 20, 1990.
249. Olney JW. Excitotoxicity and ischemic brain damage in infancy and
adulthood. In: Pharmacology of Cerebral Ischemia 1990. J Krieglstein and
H Oberpichler (Eds), Wissenschaftliche Verlagsgesell-schaft mbH, Stuttgart,
1990, pp 153-167.
250. Mosinger JL, Price MT, Bai HY, Xiao H, Wozniak DF and Olney JW.
Blockade of both NMDA and non-NMDA receptors is required for optimal
protection against ischemic neuronal degeneration in the in vivo adult
mammalian retina. Exp Neurol 113, 10-17 1991.
251. Olney JW. Excitotoxicity and neuropsychiatric disorders. In:
Glutamate, Cell Death and Memory. P Ascher, DW Choi and Y Christen (Eds),
Springer-Verlag, Berlin Heidelberg, 1991, pp 77-101.
252. Olney JW, Zorumski C, Price MT and Labruyere J. Response to Letter to
the Editor. Carbamate formation and the neurotoxicity of L-a amino acids.
Science 251,1619-1620, 1991.
253. Zorumski CF and Olney JW. Environmental excitotoxins and
neurodegenerative disorders. In: Clinics in Applied Nutrition, Volume 1,
Issue 2. R Chernoff (Ed), Andover Med Pub, Inc, 1991, pp 61-70.
254. Olney JW. Neurology. In: Academic Press Dictionary of Science and
Technology. C Morris (Ed), Harcourt Brace Inc, Pubs 1992, 1460.
255. Sesma MA, Price MT and Olney JW. Sensitivity of retinal ganglion cell
subtypes to specific excitotoxins. Investigative Ophthalmology and Visual
Science 32: Suppl, ARVO Abstract 1263 1991.
256. Zorumski CF and Olney JW. Excitotoxicity and neurodegenerative
disorders. In: Emerging Strategies in Neuroprotection. PJ Marangos and H
Lal (Eds), Birkh�user Boston, Inc., 1992, pp 326-343.
257. Olney JW, Labruyere J, Wang G, Wozniak DF, Price MT and Sesma MA. NMDA
antagonist neurotoxicity: Mechanism and prevention. Science 254:1515-1518,
1991.
258. Olney, JW. Glutamatergic mechanisms in neuropsychiatry. In: Novel
Antipsychotic Drugs. HY Meltzer (Ed), Raven Press, NY, 1992, 155-169.
259. Olney, JW. Excitotoxicity: Relevance to brain disorders in both youth
and old age. In: Biological Psychiatry, Volume 2. G Racagni, N Brunello
and T Fukuda (Eds), Elsevier Science Publishers B.V., The Netherlands,
1991, 765-768.
260. Zorumski CF and Olney JW. Acute and chronic neurodegenerative
disorders produced by dietary excitotoxins. In: The Vulnerable Brain and
Environmenal Risks Vol 2: Toxins in Food. RL Isaacson and KF Jensen (Eds),
Plenum Press, NY, 1992, pp 273-292.
261. Olney JW, Sesma MA, Labruyere J, Price MT. New evidence linking PCP
neurotoxicity in rats with PCP psychosis in humans. Neurosci Abst 17, 190,
1991.
262. Price MT, Wozniak DF, Sun S, Olney JW. Quisqualate injection into the
nucleus basalis magnocellularis induces seizure-related brain damage.
Neurosci Abst 17, 1065, 1991.
263. Wozniak DF, Stewart GR, Sun S, Olney JW. Sensitivity of basal
forebrain somatostatinergic neurons to N-methyl aspartate neurotoxicity.
Neurosci Abst 17, 1066, 1991.
264. Sesma MA, Price MT, Olney JW. Heat shock protein (HSP 72) response to
NMDA antagonists is blocked by anticholinergics or GABAmimetics. Neurosci
Abst 17, 254, 1991.
265. Romano C, Price MT, Bai HY, Olney JW. Intravitreal injection of
glucose protects against ischemic degeneration of retinal neurons. Neurosci
Abst 17, 1078 1991.
266. Wang GJ, Qin YQ, Price MT, Olney JW. Homocysteate, kainate and AMPA
induce spinal cord lesions when administered subcutaneously to infant rats.
Neurosci Abst 17, 787, 1991.
267. Tizzano JP, Schoepp DD, Price MT and Olney JW. Widespread
degeneration induced in the developing rodent CNS by D,L-2-amino-3-
phosphonopropionate (AP3). Neurosci Abst 17, 70, 1991.
268. Wozniak DF, Stewart GR, Miller JP and Olney JW. Age-related
sensitivity to kainate neurotoxicity. Exp Neurol 114, 250-253, 1991.
269. Stewart GR, Olney JW, Pathikonda M and Snider WD. Excitotoxicity in
the embryonic chick spinal cord. Ann Neurol 30: 758-766, 1991.
270. Olney, JW. Excitotoxins and neurologic diseases. Alfred Benzon
Symposium No. 32. In: Drug Research Related to Neuroactive Amino Acids. A
Schousboe, NH Diemer, H Kofod (Eds), Munksgaard, Copenhagen, 1992, pp 257-
270.
271. Olney JW, Price MT, Zorumski CF and Yamada K. Neurotoxicological
evidence for a novel benzo-diazepine site within the non-NMDA glutamate
receptor complex. Soc Neurosci Abst 18, 757, 1992.
272. Price MT, Ikonomidou C, Labruyere J, Izumi Y and Olney JW.
Neurotoxicity linked to the glutamate metabotropic receptor. Soc Neurosci
Abst 18, 83, 1992.
273. Wozniak DF, McEwen M, Brosnan-Watters G and Olney, JW. MK-801-
induced impairment on a memory task is counteracted by scopolamine. Soc
Neurosci Abst 18, 1153, 1992.
274. Farber NB, Price MT, Labruyere J, Fuller TA, Olney JW. Age
dependency of NMDA antagonist neurotoxicity. Soc Neurosci Abst 18, 1148,
1992.
275. Benz AM, Izumi Y, Clifford DB, Zorumski CF, Olney JW. Neurotoxic
effects of sodium nitroprusside in rat hippocampal slices. Soc Neurosci
Abst 18, 645, 1992.
276. Zorumski CF, Yamada K, Mennerick S, Olney JW. Electrophysiological
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receptor complex. Soc Neurosci Abst 18, 757, 1992.
277. Fink-Jensen A, Judge ME, Hansen JB, Jacobsen P, Turski L, Olney J,
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278. Olney JW, Sesma MA, Wozniak DF. Glutamatergic, cholinergic, and
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279. Romano C, Price M, Bai H-Y, Olney JW: Neuroprotectants in Honghua:
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280. Olney JW. Excitatory transmitter neurotoxicity. Neurobiol Aging
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281. Olney JW. Excitotoxicity. In: Principles of Neurotoxicology. LW
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282. Olney JW. Role of excitotoxins in developmental neuropathology.
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283. Zorumski CF, Yamada KA, Price MT, Olney JW. A benzodiazepine
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284. Lin C, Olney JW, Price MT, Romano C. The effect of ocular
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285. Romano C, Price M, Olney JW. Delayed excitotoxic neurodegeneration
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286. Olney JW. Excitatory transmitter neurotoxicity: An overview. In:
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287. Farber NB, Price MT, Labruyere J, Nemnich J, St. Peter H, Wozniak DF,
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288. Benz A, Izumi Y, Zorumski CF, Clifford DB, Price MT, Olney JW.
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by lactate infusion in hippocampal slices. Neurosci Abst 19, 1775, 1993.
289. Olney JW, Farber NB, Price MT, Labruyere J, Nemnich J, St. Peter H.
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290. Price MT, Romano C, Labruyere J., Olney JW. Degeneration of the
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291. Farber NB, Price MT, Labruyere J, Nemnich J, St. Peter H, Olney JW.
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analogs correlates with anti-psychotic efficacy. Neurosci Abst 19, 384,
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292. Wozniak DF, McEwen M, Sesma MA, Olney JW, Fix AS. MK-801 induces
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293. Brosnan-Watters G, Wozniak DF, McEwen M, Olney JW. Cerebrocortical
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294. Gallagher D, Thurkauf A, Rajachandran L, Kastello A, Cassella J,
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295. Olney JW. New mechanisms of excitatory transmitter neurotoxicity. J
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296. Olney JW. Excitotoxins in Foods. Neurotoxicology, 15(3), 535-544,
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297. Wozniak DF, Huss J and Olney JW. Quisqualate injection into the
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298. Fix AS, Schoepp DD, Olney JW, Vestre WA, Griffey KI, Johnson JA and
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299. Fix AS, Horn JW, Wightman KA, Johnson CA, Long GG, Storts RW, Farber
N, Wozniak DF and Olney JW. Neuronal vacuolization and necrosis induced by
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300. Zorumski CF and Olney JW Excitotoxic neuronal damage and
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301. Romano C, Sesma MA, McDonald CT, Price MT and Olney JW.
Immunochemical studies of a metabotropic glutamate receptor (mGluR5) in rat
brain. Soc Neurosci Abstr, 19, 926, 1993.
302. Csernansky JG, Bardgett ME, Labruyere J, Jackson JJ and Olney JW.
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303. Bardgett ME, Olney JW, Jackson JJ, Wrong CT and Csernansky JG.
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304. Romano C, Sesma MA, MacDonald CT, O�Malley K, van den Pol AN and
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305. Farber NB, Price MT, Labruyere J, Nemnich J, St. Peter H, Wozniak DF,
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306. Olney JW and Farber NB. Efficacy of clozapine compared with other
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307. Olney JW. Glutamate receptor-mediated neurotoxicity. In:
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308. Farber NB, Wozniak DF, Price MT, Labruyere J, Huss J, St. Peter H,
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309. Olney JW, Farber NB. Excitatory transmitter neurotoxicity and
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310. Olney JW, Farber NB, Corso T, Labruyere J, Zhang SX, Langlais PJ.
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311. Price MT, Farber NB, Labruyere J, Foster J, Olney JW. Tracing the
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312. Izumi Y, Benz AM, Zorumski CF, Olney JW. B-hydroxybutyrate fuels
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313. Ikonomidou C, Qin YO, Labruyere J, Olney JW. Trauma causes
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314. Farber NB, Olney JW. Rats become hyposensitive to MK-801
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315. Brosnan-Watters G, Wozniak DF, Nardi A, Olney JW, Fix AS. High dose
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316. Corso TD, Wozniak DF, Sesma MA, Olney JW. Neuron necrotizing
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317. Benz AM, Izumi Y, Zorumski CF, Clifford DB, Price MT, Olney JW. An
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318. Csernansky JG, Bardgett ME, Sheline YI, Olney J. Stage-specific
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319. Langlais PJ, Zhang SX, Weilersbacher GS, Corso T, Olney JW.
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320. Fix AS, Long GG, Wozniak DF, Olney JW. Pathomorphologic effects of
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321. Fix AS, Wozniak DF, Truex LL, McEwen M, Miller JP, Olney JW.
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322. Zhang SX, Weilersbacher GS, Henderson SW, Corso T, Olney JW, Langlais
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323. Olney JW. The neurotoxicity of NMDA receptor antagonists: An
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324. Izumi Y, Benz AM, Kirby CO, Labruyere J, Zorumski CF, Price MT, Olney
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325. Farber NB, Foster J, Olney JW. Clozapine and related analogs block
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326. Bardgett ME, Kogelman L, Sesma MA, Olney JW, Csernansky JG.
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327. Romano C, Price MT, Olney JW. Delayed excitotoxic neurodegeneration
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328. Ball RH, Bardgett ME, Olney JW. Systemic administration of the
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329. Rothman SM, Olney JW. Excitotoxicity and the NMDA receptor-still
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330. Olney JW, Farber NB. Glutamate receptor dysfunction and
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331. Ikonomidou C, Qin Y, Labruyere J, Kirby C, Olney JW. Prevention of
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332. Farber NB, Olney JW. A2 adrenergic agonists prevent NMDA antagonist
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333. Olney JW, Farber NB. NMDA receptor hypofunction and schizophrenia.
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334. Farber NB, Foster J, Duhan NL, Olney JW. A2 adrenergic agonists
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335. Olney JW, Farber, NB. NMDA antagonists as neurotherapeutic drugs,
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336. Olney JW. NMDA receptor hypofunction, excitotoxicity and Alzheimer�s
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337. Olney JW. Food additives, excitotoxic. In: Encyclopedia of
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338. Olney JW. Glutamate. In: Encyclopedia of Neuroscience 2nd Edition
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340. Ishimaru M, Fukamauchi F, Olney JW. Halothane prevents MK-801
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341. Olney JW. Glutamate and other excitatory amino acids. In:
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342. Olney JW, Ikonomidou C, Wang GJ, Qin YO, Price MT. Excitotoxic
degeneration of motor neurons resembles that seen in SOD-1 transgenic mice.
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343 Farber NB, Olney JW. Alpha-2 adrenergic agonists prevent NMDA
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344. Wozniak DF, Nardi A, Corso TD, Olney JW. Scopolamine and
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345. Romano C, Price MT, Almli T, Olney JW. Characterization of delayed
neurodegeneration induced by oxygen/glucose deprivation in isolated retina.
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346. Ikonomidou C, Der TC, Sesma MA, Qin YO, Ishimaru M, Labruyere J,
Olney JW. Cysteine-induced brain damage in neonatal rats selectively
affects GABAergic neurons. Soc Neurosci Abst 21, 521, 1995.
347. Qin YO, Ikonomidou C, Labruyere J, Bittigau P, Olney JW. Effect of
glutamate receptor antagonists on traumatic brain damage in neonatal rats.
Soc Neurosci Abst 21, 762, 1995.
348. Corso TD, Der TC, Tenkova TI, Labruyere J, Wozniak DF, Olney JW.
Disseminated neuronal necrosis induced by phencyclidine (PCP) in rat brain:
Effect of co-treatment with pilocarpine. Soc Neurosci Abst 21, 351, 1995.
349. Kirby-Sharkey CO, Izumi Y, Mennerick S, Benz AM, Labruyere J,
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transport inhibitors in the retina. Soc Neurosci Abst 21, 1861, 1995.
350. Jevtovic-Todorovic V, Ishimaru M, Price MT, Olney JW. Isoflurane,
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351. Chen Q, Olney J, Almli T, Wax M, Price, M, Romano C. Kainate-induced
delayed excitotoxicity in isolated retina. Soc Neurosci Abst 21, 1340,
1995.
352. Ishimaru M, Der TC, Tenkova TI, Sesma MA, Thurston JH, Olney JW.
Three types of excitotoxicity evaluated for �apoptosis� signals. Soc
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353. Izumi Y, Kirby-Sharkey CO, Benz AM, Labruyere J, Price MT, Wozniak
DF, Zorumski CF, Olney JW. Age dependent sensitivity of the rat retina to
the excitotoxic action of N-Methyl-D-Aspartate. Neurobiol Dis 2, 139-144,
1995.
354. Brosnan-Watters G, Wozniak DF, Nardi A, Olney JW. Acute behavioral
effects of MK-801 in the mouse. Pharmacol Biochem Behav 53(3), 701-711,
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355. Wozniak DF, Brosnan-Watters G, Nardi A, McEwen M, Corso TD, Olney JW,
Fix AS. MK-801 neurotoxicity in male mice: histologic effects and chronic
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356. Olney JW. Phencyclidine neurotoxicity. In: Encyclopedia of
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357. Ikonomidou Chrysanthy, Qin Yue Qin, Labruyere Joann, Olney John W.
Motor neuron degeneration induced by excitotoxin agonists has features in
common with that seen in the SOD-1 transgenic mouse model of amyotrophic
lateral sclerosis. J Neuropathol Exp Neurol 55(2), 211-224, 1996.
358. Rossof AH and Olney JW. Lithium effects on blood cell production and
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359. Izumi Y, Benz AM, Zorumski CF, Olney, JW. Effects of lactate and
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360. Csernansky JG, Bardgett ME, Sheline YI, Morris JC, Olney JW. CSF
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361. Romano C, Tenkova T, Price MT, Olney JW. Distribution of group 1
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362. Gehlbach P, Izumi Y, Olney JW, Romano C. Developmental expression of
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363. Ikonomidou C, Der TC, Qin YQ, Bittigau P, Olney JW. Neocortical
trauma causes distant lesions in infant rat brain. Eur J Ped Abst, 1996.
364. Stewart GR, Olney JW, Schmidt RE, Wozniak DF. Mineralization of the
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365. Olney JW, Farber NB. Response to commentaries and to the challenge
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366. Olney JW, Farber NB, Spitznagel E, Robins LN. Increasing brain tumor
rates: Is there a link to aspartame? J Neuropath Exp Neurol 55, 1115-1123,
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367. Olney JW, Eye S, Wozniak DF, Jevtovic-Todorovic V. Clonidine
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relieving action of MK-801. Soc Neurosci Abst 22, 511, 1996.
368. Ikonomidou C, Ishimaru M, Bittigau P, Der TC, Qin YQ, Olney JW.
Delayed degeneration of distant neurons following neocortical brain
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369. Farber NB, Olney JW. 5HT2A agonists prevent NMDA antagonist
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370 Newcomer JW, Farber NB, Jevtovic-Todorovic V, Selke G, Kelly A,
Williams F, Craft S, Olney JW. NMDA glutamate receptor hypofunction: A
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371. Wozniak DF , Farber NB, Nardi A, Taylor G, Olney JW. Sensitivity to
MK-801 neurotoxicity is increased in aged male rats. Soc Neurosci Abst 22,
202, 1996.
372. Jevtovic-Todorovic V, Labruyere J, Olney JW. Nitrous oxide, unlike
other anesthetic agents, fails to block MK-801 neurotoxicity. Soc Neurosci
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373. Chen Q, Olney J, Lukasiewicz P, Romano C. Mechanisms of kainate-
induced excitotoxicity in retina: Unique role of chloride. Soc Neurosci
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374. Jevtovic-Todorovic V, Kirby CO, Olney JW. Isoflurane and propofol
block neurotoxicity caused by MK-801 in the rat posterior
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375 Olney J, Wozniak D, Ishimaru M, Farber N. NMDA receptor dysfunction
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376 Farber NB, Foster J, Duhan NL, Olney JW. Olanzapine and fluperlapine
mimic clozapine in preventing MK-801 neurotoxicity. Schizophrenia Res 21,
33-37 1996.
377. Corso TD, Sesma MA, Tenkova TI, Der TC, Wozniak DF, Farber NB, Olney,
JW. Multifocal brain damage induced by phencyclidine is augmented by
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378. Izumi Y, Kirby-Sharkey CO, Benz AM, Mennerick S, Labruyere J, Price
MT, Olney JW, Zorumski CF. Swelling of M�ller cells induced by AP3 and
glutamate transport substrates in rat retina. GLIA 17, 285-293, 1996.
379. Olney JW, Ishimaru MJ. Excitotoxic Cell Death. In: Cell Death and
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380. Chen Q, Olney JW, Romano C. Pathomorphological effects of Kainate in
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1997.
381. Farber NB, Hanslick J, Kirby C, McWilliams L, Olney, JW.
Serotonergic agents that activate 5HT2A receptors prevent NMDA antagonist
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382. Olney JW, Wozniak DF, Farber NB. Excitotoxic neurodegeneration in
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383. Olney JW, Wozniak DF, Nardi A, Powell S, Jevtovic-Todorovic V.
Clonidine potentiates the neuropathic pain relieving action of MK-801 while
preventing its neurotoxic and hyperactivity side effects. Soc Neurosci
Abst, 23, 2308, 1997.
384. Farber NB, Kim SH, Olney JW. Costimulation of muscarinic and non-
NMDA glutamate receptors reproduces NMDA antagonist neurotoxicity. Soc
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385. Wozniak DF, Jevtovic-Todorovic V, Powell S, Olney JW. Propofol
protects cerebrocortical neurons against the cell killing action of MK-801.
Soc Neurosci Abst, 23, 2309, 1997.
386. Kim SH, Farber NB, Price MT, Olney JW. Clonidine suppresses MK801-
induced acetylcholine release in rat posterior cingulate cortex: in vivo
microdialysis study. Soc Neurosci Abst, 23, 2308, 1997.
387. Dikranian K, Wozniak DF, Ishimaru MJ, Price MT, Nardi A, Olney JW.
Ultrastructural evaluation of disseminated lesions induced by MK-801. Soc
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388. Chen Q, Olney J, Almli T, Romano C. Fenamates protect neurons
against ischemic and excitotoxic injury. Soc Neurosci Abst, 23, 1921, 1997.
389. Jevtovic-Todorovic V, Olney JW. Nitrous oxide: general anesthetic,
NMDA antagonist, neuroprotectant and neurotoxin. Soc Neurosci Abst, 23,
2309, 1997.
390. Ishimaru MJ, Ikonomidou C, Dikranian K, Olney JW. CNS apoptosis:
how shall it be defined and recognized? Soc Neurosci Abst, 23, 895, 1997.
391. Jevtovic-Todorovic V, Wozniak DF, Nardi A, Powell S, Olney JW.
Clonidine potentiates the neuropathic pain relieving action of MK-801 while
preventing its neurotoxic and hyperactivity side effects. Brain Res 781,
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392. Chen Q, Olney JW, Lukasiewicz PD, Almli T, Romano C. Ca2+-
independent excitotoxic neurodegeneration in isolated retina, an intact
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393. Romano C, Price MT, Almli T, Olney JW. Excitotoxic neurodegeneration
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394. Olney JW, Farber NB. N-Methyl-D-Aspartate receptor hypofunction in
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395. Olney JW, Farber NB. Discussion of Bogerts’ temporolimbic system
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396. Newcomer JW, Farber NB, Jevtovic-Todorovic V, Selke G, Melson AK,
Hershey T, Craft S, Olney JW. Ketamine-induced NMDA receptor hypofunction
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397. Jevtovic-Todorovic V, Todorovic SM, Mennerick S, Powell S, Dikranian
K, Benshoff N, Zorumski CF, Olney JW. Nitrous oxide (laughing gas) is an
NMDA antagonist, neuroprotectant and neurotoxin. Nature Medicine 4(4), 460-
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398. Ishimaru MJ, Ikonomidou C, Tenkova TI, Der TC, Dikranian K, Sesma MA,
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399. Farber NB, Newcomer JW, Olney JW. The glutamate synapse in
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400. Romano C, Chen Q, Olney JW. The intact isolated “ex vivo” retina as
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401. Romano C, Chen Q, Lukasiewicz PD, Olney JW. Ligand-gated chloride
channels opened during glutamate receptor activation essential for
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402. Marquis KL, Piesla MJ, Bramlett DR, Ochalski LA, Hartupee DA, Price
MT, Olney JW, Zaleska MM, Moyer JA. Preclinical side effect and therapeutic
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403. Weiler M, Haley S, Hoffman D, Sheler C, Meehan J, Boysen B, Olney J.
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404. Romano C, Chen Q, Almli T, Moulder K, Olney JW. Excitotoxic cell
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405. Chen Q, Olney JW, Lukasiewicz PD, Almli T, Romano C. Fenamates
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406. Pohl D, Bittigau P, Ishimaru MJ, Stadthaus D, H�bner C, Olney JW,
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407. Ikonomidou C, Bosch F, Miksa M, Bittigau P, V�ckler J, Dikranian K,
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apoptotic neurodegeneration in the developing brain. Science 283, 70-74,
1999.
408. Jevtovic-Todorovic V, Benshoff N, Olney JW. Effects of age and sex
on neurotoxicity caused by an NMDA antagonist nitrous oxide in rat cortex.
Anesthesiology Abst 89(3A), A137, 1998.
409. Olney JW, Wozniak DF, Price MT, Ikonomidou C. Alcohol induces
massive apoptotic neuro-degeneration in the developing rat CNS. Soc
Neurosci Abst, 24, 1983, 1998.
410. Farber NB, Wozniak DF, Price MT, Ikonomidou C, Olney JW. PCP
triggers apoptotic neurodegeneration in the developing rat CNS. Soc
Neurosci Abst, 24, 771, 1998.
411. Wozniak DF, Dikranian K, Ishimaru MJ, Tenkova T, Ikonomidou C, Olney
JW. Histological characterization of apoptotic neurodegeneration induced in
the developing rat CNS by alcohol and PCP. Soc Neurosci Abst, 24, 2168,
1998.
412. Jevtovic-Todorovic V, Olney JW, Farber NB. Lamotrigine prevents NMDA
antagonist neurotoxicity. Soc Neurosci Abst, 24, 745, 1998.
413. Dikranian K, Ishimaru MJ, Tenkova T, Ikonomidou C, Olney JW.
Histological characterization of apoptotic neurodegeneration induced in the
developing rat CNS by NMDA antagonists. Soc Neurosci Abst, 24, 1299. 1998.
414. Kim SH, Olney JW, Farber NB. Clonidine prevents NMDA antagonist
neurotoxicity by activating *2 adrenergic receptors in the diagnonal band.
Soc Neurosci Abst, 24, 462, 1998.
415. Nardi A, Wozniak DF, Brosnan-Watters G, Farber NB, Olney JW. MK-801
disrupts prepulse inhibition of acoustic startle in male mice. Soc Neurosci
Abst, 24, 746, 1998.
416. Mennerick S, Jevtovic-Todorovic V, Todorovic SM, Olney JW, Zorumski
CF. Effects of nitrous oxide (laughing gas) on excitatory and inhibitory
neurotransmission. Soc Neurosci Abst, 24, 324, 1998.
417. Ikonomidou C, Bosch F, Bittigau P, Miksa M, Turski L, Olney JW. NMDA
antagonists induce massive apoptotic neurodegeneration in the developing rat
CNS. Soc Neurosci Abst, 24, 274, 1998.
418. Newcomer JW, Farber NB, Selke G, Melson AK, Jevtovic-Todorovic V, Olney
JW. Guanabenz effects on NMDA antagonist-induced mental symptoms in humans.
Soc Neurosci Abst, 24, 525, 1998.
419. Chen Q, Olney JW, Price MT, Romano C. Biochemical and morphological
analysis of non-NMDA receptor mediated excitotoxicity in chick embryo
retina. Visual Neurosci 16, 131-139, 1999.
420. Mennerick S, Jevtovic-Todorovic V, Todorovic SM, Shen W, Olney JW,
Zorumski CF. Effect of nitrous oxide on excitatory and inhibitory synaptic
transmission in hippocampal cultures. J Neurosci 18, 9716-9726, 1998.
421. Bittigau P, Sifringer M, Pohl D, Stadthaus D, Ishimaru M, Shimizu H,
Ikeda M, Lang D, Speer A, Olney JW, Ikonomidou C. Apoptotic
neurodegeneration following trauma is markedly enhanced in the immature
brain. Ann Neurol 45(6), 724-735, 1999.
422. Brosnan-Watters G, Wozniak DF, Nardi A, Olney JW. Parallel recovery of
MK-801-induced spatial learning impairment and neuronal injury in male mice.
Pharmacol Biochem Behav 62, 111-122, 1999.
423. Farber NB, Newcomer JW, Wozniak DF, Olney JW. Neurodegeneration
induced by NMDA glutamate receptor hypofunction: Implications for
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Volume 2. (Eds) Springer Pub, NY, 1999, pp 72-79.
424. Farber NB, Newcomer JW, Olney JW. Glycine Agonists: What can they
teach us about Schizophrenia? Arch Gen Psychiatry 56, 13-17, 1999.
425. Wozniak DF, Dikranian K, Ishimaru M, Nardi A, Corso TD, Olney JW, Fix
AS. Disseminated corticolimbic neuronal degeneration induced in rat brain
by MK-801. Neurobiol Dis 5, 305-322, 1999.
426. Kim SH, Price MT, Olney JW, Farber NB. Excessive cerebrocortical
release of acetylcholine induced by NMDA antagonists is reduced by gabaergic
and -2adrenergic agonists. Mol Psychiatry 4: 344-352, 1999.
427. Izumi Y, Kirby C, Benz A, Olney JW, Zorumski CF. M�ller cell
swelling, glutamate uptake and excitotoxic neurodegeneration in the isolated
rat retina. GLIA 25, 379-389, 1999.
428. Farber NB. Newcomer JW, Olney JW. NMDA receptor hypofunction, loss
of gabaergic inhibition and schizophrenia. Abstract, WPA Meeting, Hamburg,
Germany, (in press) August 1999.
429. Izumi Y, Benz AM, Hammerman SB, Kirby CO, Zorumski CF, Olney JW.
Involvement of glutamate in ischemic neurodegeneration in isolated retina.
Arvo abstract Meeting (in press) 1999.
430. Olney JW, Wozniak DF, Farber NB. Glutamate receptor dysfunction and
Alzheimer�s disease. Restor Neurol Neurosci 13, 75-83, 1998.
431. Jevtovic-Todorovic V, Benshoff N, Olney JW. Prolonged nitrous oxide
anesthesia kills neurons in the adult brain. J Neurosurg Anesth Abst
10(4):257,1998.
432. Ikonomidou C, Bittigau P, Ishimaru MJ, Wozniak DF, Koch C, Genz K,
Price MT, Stefovska V, H�rster F, Tenkova T, Dikranian K, Olney JW. Ethanol-
induced apoptotic neurodegeneration and fetal alcohol syndrome. Sci ence
287, 1056-1060, 2000.
Farber NB, Newcomer JW, Olney JW. Commentary, Arch Gen Psychiatry , 1999.
Newcomer JW, Selke G, Melson AK, White DA, Roediger HL, Farber NB, Wozniak
D, Jevtovic-Todorovic V, Olney JW. NMDA antagonist-induced decreases in
working and explicit memory in humans. Soc Neurosci Abst 25, 633, 1999.
Benz AM, Izumi Y, Hammerman SB, Aoki M, Olney JW, Zorumski CF. Effects of
fructose-1,6-diphosphate on morphological and functional neuronal integrity
of rat hippocampal slices during energy deprivation. Soc Neurosci Abst, 25,
1846, 1999.
Wozniak DF, Hartman RE, Nardi A, Olney JW, Holtzman DM. APOE4 transgenic
male mice are profoundly impaired on the working memory protocol of the
radial arm maze. Soc Neurosci Abst, 25, 55, 1999.
Jevtovic-Todorovic V, Newcomer JW, Olney JW, Farber NB. Pilocarpine
reverses clozapine�s and olanzapine�s prevention of NMDA antagonists
neurotoxicity (NAN). Soc Neurosci Abst, 25, 1817, 1999.
Hartman RE, Nardi A, Jevtovic-Todorovic V, Ikonomidou C, Olney JW, Wozniak
DF. Brief ethanol exposure during synaptogenesis leads to increased pain
sensitivity in adult male rats. Soc Neurosci Abst, 25, 486, 1999.
Price MT, Wozniak DF, Tenkova T, Dikranian K, Ikonomidou C, Olney JW.
Ethanol induces widespread apoptotic neurodegeneration in the fetal guinea
pig brain. Soc Neurosci Abst, 25, 550, 1999.
Olney JW, Wozniak DF, Price MT, Tenkova T, Dikranian K, Ikonomidou C.
Ethanol induces widespread apoptotic neurodegeneration in the infant mouse
brain. Soc Neurosci Abst, 25, 550, 1999.
Farber NB, Price MT, Ikonomidou C, Olney JW. Action of ethanol at GABAA
receptors blocks neurotoxicity in the adult brain, but augments
neurotoxicity in the developing brain. . Soc Neurosci Abst, 25, 551, 1999.
Bittigau, P, Genz K, Bosch-H�rster F, V�ckler J, Dikranian K, Tenkova T,
Olney JW, Ikonomidou C. Barbiturates and benzodiazepines cause apoptotic
neurodegeneration in the developing rat brain. Soc Neurosci Abst, 25, 551,
1999.
Dikranian K, Tenkova T, Ikonomidou C and Olney JW. Histological
characterization of apoptotic neurodegeneration induced in the developing
rodent brain by barbiturates and benzodiazepines. Soc Neurosci Abst, 25,
1777, 1999.
Olney JW, Newcomer JW, Farber NB. NMDA receptor hypofunction model of
schizophrenia. J Psychiatr Res, 33:523-533, 1999.
Chen Q, Moulder K, Tenkova T, Hardy K, Olney JW, Romano C. Excitotoxic cell
death dependent on inhibitory receptor activation. Exp Neurol 160,215-225,
1999.
446. Farber NB, Newcomer JW, Olney JW . Glutamatergic transmission:
Therapeutic prospects for schizophrenia and Alzheimer�s disease. In:
Glutamate and GABA Receptors and Transporters: Structure , Function and
Pharmacology. (in press) 1999
447. Holtzman DM, Tenkova TI, Bales KR, Paul SM, Olney JW, McKeel DW,
Wozniak DF. Marked neuritic degeneration is apolipoprotein E-dependent in
the APPV717F mouse model of Alzheimer�s Disease. Soc Neurosci Abst 25,
1058, 1999.
448. Holtzman DM, Bales KR, Tenkova TI, Fagan AM, Parsadanian M, Sartorius
LJ, Mackey B, Olney JW, McKeel DW, Wozniak DF, Paul SM. Apolipoprotein E
isoform-dependent amyloid deposition and neuritic degeneration in a mouse
model of Alzheimer�s disease. Proc Nat Acad Sci, 97:2892-2897, 2000.
449. Ikonomidou C, Bittigau P, Ishimaru MJ, Wozniak DF, Koch C, Genz K,
Price MT, Stefovska V, H�rster F, Tenkova T, Dikranian K, Olney JW. Induced
damage in the developing brain. Science 288: 976-977, 2000..
450. Bittigau, P., Pohl. D., Sifrtinger, M., Shimizu H., Ikeda M.,
Ishimaru M.J., Stadthaus D., Fuhr S., Dikranian K., Olney J.W., Ikonomidou
C. (1998) Modeling periatric trauma: Mechanisms of neurodegeneration and
potential strategies for neuroprotection. Restorative Neurology and
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451. Olney JW, Ishimaru MJ, Bittigau P, Ikonomidou C. Ethanol-induced
apoptotic neurodegeneration in the developing brain. Apoptosis 5/6:515-521,
2000.
452. Jevtovic-Todorovic V, Wozniak DF, Powell S, Olney JW. Propofol and
sodium thiopental protect against MK-801-induced neuronal necrosis in the
posterior cingulate/retrosplenial cortex. Brain Res 895:264-267, 2001.
453. Olney JW, Farber NB, Wozniak DF, Jevtovic-Todorovic V, Ikonomidou C.
Environmental agents that have the potential to trigger massive apoptotic
neurodegeneration in the developing brain. Environ Health Perspect 108 Sup
3, 383-388, 2000.
454. Izumi Y, Hammerman SB, Benz AM, Labruyere J, Zorumski CF, Olney JW.
Comparison of rat retinal fixation techniques: Chemical fixation and
microwave irradiation. Exp Eye Res 70, 191-198, 2000.
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mechanisms and circuitry underlying NMDA antagonist neurotoxicity. Mol
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456. Olney JW, Newcomer JW, Farber NB. Response to letter to editor.
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457. Dikranian K, Ishimaru MJ, Tenkova T, Labruyere J, Qin YQ, Ikonomidou
C, Olney, JW. Apoptosis in the in vivo mammalian forebrain. Neurobiol Dis
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458. Olney JW. Alcohol damage to the brain. In: Encyclopedia of the
Human Brain. VS Ramachandran (Ed), Academic Press. San Diego, CA (in press)
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459. Olney JW, Price MT, Labruyere J, Tenkova T. Perinatal
hypoxia/ischemia kills neurons directly by excitotoxic necrosis and
indirectly by deafferentation apoptosis. Soc Neurosci Abst 26, 1880, 2000.
460. Price MT, Tenkova T, Cai WH, Olney JW. Ethanol-induced apoptosis in
the visual system during synaptogenesis . Soc Neurosci Abst 26, 324, 2000.
461. Farber NB, Price MT, Olney JW. Ethanol protects against its own
neurotoxic potential by a mechanism that may not be failsafe. Soc Neurosci
Abst 26, 801, 2000.
462. Ikonomidou C, Genz K, Engelbrechten Sv, Dikranian K, Olney JW,
Bittigau P. Antiepileptic drugs which block sodium channels cause neuronal
apoptosis in the developing rat brain. Soc Neurosci Abst 26, 323, 2000.
463. Bittigau P, Genz K, Engelbrechten Sv, Hoerster F, Dikranian K, Olney
JW, Ikonomidou C. Antiepileptics which enhance GABA-ergic inhibition cause
neuronal apoptosis in the developing CNS. Soc Neurosci Abst 26, 323, 2000.
464. Dikranian K, Tenkova T, Bittigau P, Ikonomidou C, Olney JW.
Histological characterization of apoptotic neurodegeneration induced in the
developing rat brain by drugs that block sodium channels. Soc Neurosci Abst
26, 323, 2000.
465. Jevtovic-Todorovic V, Benshoff N, Olney JW. GABAergic agents
(Isoflurane and barbiturates) trigger widespread apoptotic neurodegeneration
in the infant rat brain. Soc Neurosci Abst 26, 323, 2000.
466. Meyenburg A, Olney JW, Wozniak DF, Newcomer JW, Jevtovic-Todorovic V.
Combined treatment with memantine and an a2 adrenergic agonist provides safe
and effective relief from neuropathic pain. Soc Neurosci Abst 26, 2191,
2000.
467. Tenkova T, Price MT, Labruyere J, Olney JW. Drug-induced apoptosis
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